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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1997-7-28
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pubmed:abstractText |
Mice deficient in the p65 subunit of NF-kappaB die during fetal development. Introduction of p50/p65-deficient fetal liver cells into lethally irradiated hosts resulted in a severe deficit of fetal liver-derived lymphocytes and their immediate precursors but an overabundance of fetal liver-derived granulocytes. Surprisingly, simultaneous transplantation of wild-type bone marrow cells rescued the production of p50/p65-deficient lymphocytes. Expression of immunoglobulin K light chains on these rescued NF-kappaB-deficient B lymphocytes was normal. These results suggest that while p50 and p65 do not regulate the maturation of pre-B cells, NF-kappaB mediates the development or survival of an early lymphocyte precursor through regulation of an extracellular factor.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
765-72
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9208848-Adoptive Transfer,
pubmed-meshheading:9208848-Animals,
pubmed-meshheading:9208848-B-Lymphocytes,
pubmed-meshheading:9208848-Bone Marrow Cells,
pubmed-meshheading:9208848-Cells, Cultured,
pubmed-meshheading:9208848-Flow Cytometry,
pubmed-meshheading:9208848-Gene Rearrangement, B-Lymphocyte,
pubmed-meshheading:9208848-Granulocytes,
pubmed-meshheading:9208848-Hematopoiesis,
pubmed-meshheading:9208848-Hematopoietic Stem Cells,
pubmed-meshheading:9208848-Immunoglobulin kappa-Chains,
pubmed-meshheading:9208848-Immunoglobulin lambda-Chains,
pubmed-meshheading:9208848-Liver,
pubmed-meshheading:9208848-Mice,
pubmed-meshheading:9208848-Mice, Inbred C57BL,
pubmed-meshheading:9208848-NF-kappa B,
pubmed-meshheading:9208848-NF-kappa B p50 Subunit,
pubmed-meshheading:9208848-Radiation Chimera,
pubmed-meshheading:9208848-Spleen,
pubmed-meshheading:9208848-T-Lymphocytes,
pubmed-meshheading:9208848-Thymus Gland,
pubmed-meshheading:9208848-Transcription Factor RelA
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pubmed:year |
1997
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pubmed:articleTitle |
Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cells.
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pubmed:affiliation |
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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