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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1997-7-28
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pubmed:abstractText |
The interleukin-3 family of cytokines, which play an important role in the development of myeloid lineages, transduce signals through the JAK-STAT pathway. Previous studies demonstrate that this process entails the activation of four distinct isoforms of STAT5, where two shorter isoforms are activated in a distinct population of cells. We now demonstrate that the shorter isoforms represent carboxy-terminal truncations. Moreover, these truncations are not generated by RNA processing, but by a specific proteolytic activity. Consistent with the notion that truncated STAT5 isoforms transduce distinct signals, they fail to promote the activation of several known interleukin-3 target genes. These studies suggest that the activity of a specific protease may play a critical role in defining the biological responses transduced by STAT5.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
691-701
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9208842-Cells, Cultured,
pubmed-meshheading:9208842-DNA-Binding Proteins,
pubmed-meshheading:9208842-Gene Expression Regulation,
pubmed-meshheading:9208842-Humans,
pubmed-meshheading:9208842-Interleukin-3,
pubmed-meshheading:9208842-Milk Proteins,
pubmed-meshheading:9208842-Molecular Weight,
pubmed-meshheading:9208842-Protein Processing, Post-Translational,
pubmed-meshheading:9208842-RNA, Messenger,
pubmed-meshheading:9208842-RNA Processing, Post-Transcriptional,
pubmed-meshheading:9208842-STAT5 Transcription Factor,
pubmed-meshheading:9208842-Signal Transduction,
pubmed-meshheading:9208842-Structure-Activity Relationship,
pubmed-meshheading:9208842-Trans-Activators
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pubmed:year |
1997
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pubmed:articleTitle |
Functionally distinct isoforms of STAT5 are generated by protein processing.
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pubmed:affiliation |
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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