Linked Life Data

9208161

Source:http://linkedlifedata.com/resource/pubmed/id/9208161

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-8-20
pubmed:abstractText
Methodological problems in the low level lead studies are reviewed using the Aarhus lead study as an example. It is shown that a lead effect can be found in an area where the background blood lead level is as low as 37 micrograms/l (geometric mean). Even in such an area it is worthwhile looking for populations at risk. It is shown that attrition causes confounding with a directional bias towards the null-hypothesis. Longitudinal studies are associated with this type of bias. Misclassification as for past exposures will also have a bias of this type. Studies depending on blood-lead measures are liable to have this type of bias. This is the case to a lesser degree in studies using cumulated indices. Subsamples of tooth dentin (circumpulpal dentin) satisfies the requirement for an index for cumulated lead absorption. Since lead absorption requires motor abilities, medical factors that are risk factors for motor development as well as for the other developmental outcome are also confined with a directional bias towards the null-hypothesis. It is suggested to exclude for such factors. Lead seems to be a ubiquitous noxious substance. Any community should have a strategy to minimize its effects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1210-7778
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
70-4
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Methodological problems in assessing health-related, neuropsychological effects of lead absorption in a very low-level exposed area.
pubmed:affiliation
Pediatric Department, University Hospital of Aarhus, Denmark.
pubmed:publicationType
Journal Article