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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1997-7-15
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pubmed:abstractText |
Recent hypotheses to explain the etiology of abnormal growth associated with prostate disease have invoked perturbations in the rate of apoptosis as an important contributor to the onset and progression of these diseases. For this reason, the apoptosis suppressing oncoprotein bcl-2 has come under scrutiny with regards to its role in prostate diseases. In order to evaluate the role of bcl-2 in human prostate disease and to develop an animal model to test anti-bcl-2 therapies, we generated transgenic mice in which bcl-2 expression is targeted to the mouse prostate gland.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0270-4137
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
16-26
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9207953-Animals,
pubmed-meshheading:9207953-Apoptosis,
pubmed-meshheading:9207953-Autoradiography,
pubmed-meshheading:9207953-Blotting, Southern,
pubmed-meshheading:9207953-Blotting, Western,
pubmed-meshheading:9207953-DNA, Complementary,
pubmed-meshheading:9207953-DNA Primers,
pubmed-meshheading:9207953-Disease Models, Animal,
pubmed-meshheading:9207953-Female,
pubmed-meshheading:9207953-Gene Expression Regulation,
pubmed-meshheading:9207953-Humans,
pubmed-meshheading:9207953-Male,
pubmed-meshheading:9207953-Mice,
pubmed-meshheading:9207953-Mice, Inbred Strains,
pubmed-meshheading:9207953-Mice, Transgenic,
pubmed-meshheading:9207953-Ovary,
pubmed-meshheading:9207953-Polymerase Chain Reaction,
pubmed-meshheading:9207953-Prostate,
pubmed-meshheading:9207953-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:9207953-Testis
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pubmed:year |
1997
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pubmed:articleTitle |
Abnormal prostate development in C3(1)-bcl-2 transgenic mice.
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pubmed:affiliation |
Department of Urology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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