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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1997-7-17
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pubmed:abstractText |
Mother-to-infant transmission of hepatitis G virus (HGV [or GBV-C]) was studied in sera from 42 mothers at high risk for bloodborne infections and from their 45 infants (3 twin pairs). Seven (17%) of the mothers had HGV RNA in serum by a polymerase chain reaction assay. One of the 8 (12.5%) infants born to HGV-infected mothers became positive for HGV at 3 months of age. He remained HGV-infected throughout the study (42 months), with no signs of liver disease. His twin sister remained HGV-negative despite the presence of serum and salivary HGV in both the mother and the brother. Analysis of HGV sequences from the infected mother and the infected child confirmed a genetic link between the virus of the mother and the infected child. Thus, mother-to-infant transmission of HGV, presumably occurring at partus, may cause persistent HGV viremia.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1899
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
176
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
281-5
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9207383-Amino Acid Sequence,
pubmed-meshheading:9207383-Base Sequence,
pubmed-meshheading:9207383-Female,
pubmed-meshheading:9207383-Flaviviridae,
pubmed-meshheading:9207383-Hepatitis, Viral, Human,
pubmed-meshheading:9207383-Humans,
pubmed-meshheading:9207383-Infant, Newborn,
pubmed-meshheading:9207383-Infectious Disease Transmission, Vertical,
pubmed-meshheading:9207383-Molecular Sequence Data,
pubmed-meshheading:9207383-Polymerase Chain Reaction,
pubmed-meshheading:9207383-Pregnancy,
pubmed-meshheading:9207383-RNA, Viral
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pubmed:year |
1997
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pubmed:articleTitle |
Genetic evidence for mother-to-infant transmission of hepatitis G virus.
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pubmed:affiliation |
Department of Pediatrics, Karolinska Institutet, Huddinge University Hospital, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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