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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1997-7-24
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pubmed:abstractText |
The present study was designed to investigate whether heparin-binding epidermal growth factor-like growth factor and its related peptides are expressed in response to gastrin in rat stomach. Rat gastrin-17I (2.5 nmol/kg/hour) or gastrin-17I plus gastrin receptor antagonist, L-740,093 (2.0 mg/kg/hour), was injected intravenously into male Sprague-Dawley rats. RNA was extracted from oxyntic mucosa, and heparin-binding epidermal growth factor-like growth factor and related peptide gene expression was estimated using a ribonuclease protection assay. The level of transforming growth factor-alpha mRNA did not change at any time point during the experiment. In contrast, the levels of heparin-binding epidermal growth factor-like growth factor and amphiregulin mRNA were significantly increased within 3 hours following gastrin infusion and reached maximum levels 6 and 12 hours later, respectively. Continuous infusion of gastrin significantly increased oxyntic mucosal proliferation. Gastrin receptor antagonist significantly inhibited gastrin-induced heparin-binding epidermal growth factor-like growth factor and amphiregulin gene expression and gastrin-induced oxyntic mucosal proliferation. These findings indicate that heparin-binding epidermal growth factor-like growth factor and amphiregulin genes are induced by gastrin and that they play a role in the trophic action of gastrin on oxyntic mucosa.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benzodiazepinones,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Gastrins,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Heparin,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/L 740093,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylurea Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA Probes,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Cholecystokinin B,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cholecystokinin,
http://linkedlifedata.com/resource/pubmed/chemical/amphiregulin,
http://linkedlifedata.com/resource/pubmed/chemical/heparin-binding EGF-like growth...
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0006-291X
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pubmed:author |
pubmed-author:HigashimotoYY,
pubmed-author:HigashiyamaSS,
pubmed-author:HiraokaSS,
pubmed-author:KanayamaSS,
pubmed-author:KitamuraSS,
pubmed-author:MatsuzawaYY,
pubmed-author:MinamiTT,
pubmed-author:MiyagawaJJ,
pubmed-author:MiyazakiYY,
pubmed-author:MurayamaYY,
pubmed-author:ShinomuraYY,
pubmed-author:TaniguchiNN,
pubmed-author:TsutsuiSS
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
235
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
520-3
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:9207188-Animals,
pubmed-meshheading:9207188-Benzodiazepinones,
pubmed-meshheading:9207188-DNA, Complementary,
pubmed-meshheading:9207188-Epidermal Growth Factor,
pubmed-meshheading:9207188-Gastric Mucosa,
pubmed-meshheading:9207188-Gastrins,
pubmed-meshheading:9207188-Glycoproteins,
pubmed-meshheading:9207188-Growth Substances,
pubmed-meshheading:9207188-Heparin,
pubmed-meshheading:9207188-Infusions, Intravenous,
pubmed-meshheading:9207188-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:9207188-Kinetics,
pubmed-meshheading:9207188-Male,
pubmed-meshheading:9207188-Parietal Cells, Gastric,
pubmed-meshheading:9207188-Phenylurea Compounds,
pubmed-meshheading:9207188-RNA, Messenger,
pubmed-meshheading:9207188-RNA Probes,
pubmed-meshheading:9207188-Rats,
pubmed-meshheading:9207188-Rats, Sprague-Dawley,
pubmed-meshheading:9207188-Receptor, Cholecystokinin B,
pubmed-meshheading:9207188-Receptors, Cholecystokinin,
pubmed-meshheading:9207188-Transcription, Genetic
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pubmed:year |
1997
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pubmed:articleTitle |
Induction of heparin binding epidermal growth factor-like growth factor and amphiregulin mRNAs by gastrin in the rat stomach.
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pubmed:affiliation |
Second Department of Internal Medicine, Osaka University Medical School, Suita, Japan. Shusaku_Tsutsui@msn.com
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pubmed:publicationType |
Journal Article
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