| pubmed-article:9206995 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9206995 | lifeskim:mentions | umls-concept:C0026926 | lld:lifeskim |
| pubmed-article:9206995 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:9206995 | lifeskim:mentions | umls-concept:C0123759 | lld:lifeskim |
| pubmed-article:9206995 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:9206995 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:9206995 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9206995 | pubmed:dateCreated | 1997-8-1 | lld:pubmed |
| pubmed-article:9206995 | pubmed:abstractText | Immunity to Mycobacterium tuberculosis infection is associated with the emergence of protective CD4 T cells that secrete cytokines, resulting in activation of macrophages and the recruitment of monocytes to initiate granuloma formation. The cytokine-mediating macrophage activation is interferon-gamma (IFN-gamma), which is largely dependent on interleukin-12 (IL-12) for its induction. To address the role of IL-12 in immunity to tuberculosis, IL-12 p40(-/-) mice were infected with M. tuberculosis and their capacity to control bacterial growth and other characteristics of their immune response were determined. The IL-12 p40(-/-) mice were unable to control bacterial growth and this appeared to be linked to the absence of both innate and acquired sources of IFN-gamma. T cell activation as measured by delayed type hypersensitivity and lymphocyte accumulation at the site of infection were both markedly reduced in the IL-12 p40(-/-) mice. Therefore, IL-12 is essential to the generation of a protective immune response to M. tuberculosis, with its main functions being the induction of the expression of IFN-gamma and the activation of antigen-specific lymphocytes capable of creating a protective granuloma. | lld:pubmed |
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| pubmed-article:9206995 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9206995 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9206995 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9206995 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9206995 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9206995 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:9206995 | pubmed:author | pubmed-author:CooperA MAM | lld:pubmed |
| pubmed-article:9206995 | pubmed:author | pubmed-author:OrmeI MIM | lld:pubmed |
| pubmed-article:9206995 | pubmed:author | pubmed-author:FerranteJJ | lld:pubmed |
| pubmed-article:9206995 | pubmed:author | pubmed-author:MagramJJ | lld:pubmed |
| pubmed-article:9206995 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9206995 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:9206995 | pubmed:volume | 186 | lld:pubmed |
| pubmed-article:9206995 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9206995 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9206995 | pubmed:pagination | 39-45 | lld:pubmed |
| pubmed-article:9206995 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:9206995 | pubmed:meshHeading | pubmed-meshheading:9206995-... | lld:pubmed |
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| pubmed-article:9206995 | pubmed:meshHeading | pubmed-meshheading:9206995-... | lld:pubmed |
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| pubmed-article:9206995 | pubmed:meshHeading | pubmed-meshheading:9206995-... | lld:pubmed |
| pubmed-article:9206995 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9206995 | pubmed:articleTitle | Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosis. | lld:pubmed |
| pubmed-article:9206995 | pubmed:affiliation | Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA. | lld:pubmed |
| pubmed-article:9206995 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9206995 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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