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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1997-8-1
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pubmed:abstractText |
Immunity to Mycobacterium tuberculosis infection is associated with the emergence of protective CD4 T cells that secrete cytokines, resulting in activation of macrophages and the recruitment of monocytes to initiate granuloma formation. The cytokine-mediating macrophage activation is interferon-gamma (IFN-gamma), which is largely dependent on interleukin-12 (IL-12) for its induction. To address the role of IL-12 in immunity to tuberculosis, IL-12 p40(-/-) mice were infected with M. tuberculosis and their capacity to control bacterial growth and other characteristics of their immune response were determined. The IL-12 p40(-/-) mice were unable to control bacterial growth and this appeared to be linked to the absence of both innate and acquired sources of IFN-gamma. T cell activation as measured by delayed type hypersensitivity and lymphocyte accumulation at the site of infection were both markedly reduced in the IL-12 p40(-/-) mice. Therefore, IL-12 is essential to the generation of a protective immune response to M. tuberculosis, with its main functions being the induction of the expression of IFN-gamma and the activation of antigen-specific lymphocytes capable of creating a protective granuloma.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-1357073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-1699135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-1727865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-1937752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-3097148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-3129497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-3345049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-6343467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-7477296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-7495294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-7495515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-7504064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-7516409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-7558306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-7642254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-7650381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-7751026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-7796298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-7836926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-7907877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-8096238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-8097338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-8100846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-8245795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-8568246,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-8943050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-8985251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-8999548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-9053457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9206995-9120387
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
186
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
39-45
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1997
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pubmed:articleTitle |
Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosis.
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pubmed:affiliation |
Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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