Linked Life Data

9206902

Source:http://linkedlifedata.com/resource/pubmed/id/9206902

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1997-6-30
pubmed:abstractText
We analyzed 20 cases with brain metastases from colon or rectum carcinoma. Fourteen were treated with radiotherapy alone (total dose 30-60 Gy), six with neurosurgery plus radiotherapy (total dose 30-40 Gy). All patients had advanced primary tumours (T3 and T4), most of which were poorly differentiated; lymph node metastases were common. In 5 patients (25%) the brain was the first site of distant metastases. Ten patients (50%) had a solitary brain metastasis. As a tendency, the results of surgery plus radiotherapy were superior to those of radiotherapy alone, with respect to palliation of symptoms as well as to local tumour remission and survival. Overall median survival was only 51 days. The 1-year survival rate was 6%. In 5 of 14 cases (36%) symptomatic improvement was observed after radiotherapy alone. Partial remission of the brain metastases occurred in 3 of 14 cases (21%). The presence of extracerebral metastases was the most important prognostic factor. Selected patients considered to have a favourable prognosis may profit from combined treatment, i.e. neurosurgery plus radiotherapy. Despite the short survival time, stereotactic irradiation should be evaluated as an alternative to conventional radiotherapy in the remaining patients because the palliative effect of fractionated external irradiation is relatively disappointing.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0043-5325
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
109
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
239-43
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
[Brain metastases of colon and rectum carcinomas].
pubmed:affiliation
Abteilung für Strahlentherapie Radiologische Universitätsklinik, Bundesrepublik Deutschland.
pubmed:publicationType
Journal Article, English Abstract