Linked Life Data

9205478

Source:http://linkedlifedata.com/resource/pubmed/id/9205478

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
1997-7-22
pubmed:abstractText
LEPTINE: Produced by adipose tissue, leptine is a regulatory hormone controlling body fat mass. GENETICS: The human gene coding for leptine was first cloned in 1984. Its receptor, a member of the class 1 cytokine receptor family, has also been identified. VARIABLE SERUM LEVELS: Plasma levels of leptine in normal-weight subjects are in the 5ng/ml range and reach 50 ng/ml in obese subjects. Weight gain leads to higher blood levels and weight loss to lower levels. The effect of leptine is to approach a weight equilibrium. Leptine level is correlated with energy balance. MODE OF ACTION: Leptine acts on hypothalamic centers controlling satiety. One of the essential mediators is neuropeptide Y. Resistance to leptine has been evidenced in human obesity. Resistance can occur as several levels and would be one of the explanations for massive obesity involving genetic factors. Leptine may also play a role in certain types of infertility.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0755-4982
pubmed:author
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
770-3
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
[Leptin: a genetic solution to obesity?].
pubmed:affiliation
Service d'Endocrinologie, Diabétologie, Nutrition, Hôpital Henri Mondor, Créteil.
pubmed:publicationType
Journal Article, English Abstract