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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1997-7-18
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pubmed:abstractText |
Bronchiolitis obliterans (OB) is a lesion that results when injury to small conducting airways is repaired by a proliferation of fibrous granulation tissue. Bronchiolitis obliterans has emerged as a main cause of morbidity and mortality in the setting of lung and heart-lung transplantation. Endothelin-1 (ET-1), initially discovered as a vasoconstrictive peptide, has a mitogenic activity on vascular smooth cells and airway epithelial cells. Overproduction of endothelin has been reported in patients with OB or chronic rejection after lung transplantation. It is still undetermined whether locally overexpressed ET-1 has a potential impact in the pathogenesis of OB.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0003-4975
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1562-7
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pubmed:dateRevised |
2006-5-1
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pubmed:meshHeading |
pubmed-meshheading:9205148-Animals,
pubmed-meshheading:9205148-Bronchi,
pubmed-meshheading:9205148-Bronchiolitis Obliterans,
pubmed-meshheading:9205148-Disease Models, Animal,
pubmed-meshheading:9205148-Endothelin-1,
pubmed-meshheading:9205148-Endothelium, Vascular,
pubmed-meshheading:9205148-Epithelium,
pubmed-meshheading:9205148-Gene Transfer Techniques,
pubmed-meshheading:9205148-Genetic Vectors,
pubmed-meshheading:9205148-Liposomes,
pubmed-meshheading:9205148-Macrophages, Alveolar,
pubmed-meshheading:9205148-Male,
pubmed-meshheading:9205148-Plasmids,
pubmed-meshheading:9205148-Pulmonary Alveoli,
pubmed-meshheading:9205148-Rats,
pubmed-meshheading:9205148-Rats, Wistar,
pubmed-meshheading:9205148-Respirovirus,
pubmed-meshheading:9205148-Transfection,
pubmed-meshheading:9205148-beta-Galactosidase
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pubmed:year |
1997
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pubmed:articleTitle |
Experimental bronchiolitis obliterans induced by in vivo HVJ-liposome-mediated endothelin-1 gene transfer.
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pubmed:affiliation |
First Department of Surgery, Institute for Cellular and Molecular Biology, Osaka University Medical School, Suita, Japan. stakeda@surg1.med.osaka-u.ac.jp
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pubmed:publicationType |
Journal Article
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