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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5322
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pubmed:dateCreated |
1997-7-21
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pubmed:abstractText |
Bovine spongiform encephalopathy (BSE) has become a public health issue because a recently evolved BSE agent has infected people, yielding an unusual form of Creutzfeld-Jakob disease (CJD). A new CJD agent that provokes similar amyloid plaques and cerebellar pathology was serially propagated. First-passage rats showed obvious clinical signs and activated microglia but had negligible PrP-res (the more protease-resistant form of host PrP) or cerebellar lesions. Microglia and astrocytes may participate in strain selection because the agent evolved, stabilized, and reproducibly provoked BSE-like disease in subsequent passages. Early vacuolar change involving activated microglia and astrocytes preceded significant PrP-res accumulation by more than 50 days. These studies reveal several inflammatory host reactions to an exogenous agent.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
277
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
94-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9204907-Amyloid beta-Protein Precursor,
pubmed-meshheading:9204907-Animals,
pubmed-meshheading:9204907-Astrocytes,
pubmed-meshheading:9204907-Brain,
pubmed-meshheading:9204907-Brain Chemistry,
pubmed-meshheading:9204907-Cerebellum,
pubmed-meshheading:9204907-Clusterin,
pubmed-meshheading:9204907-Creutzfeldt-Jakob Syndrome,
pubmed-meshheading:9204907-Cricetinae,
pubmed-meshheading:9204907-Cricetulus,
pubmed-meshheading:9204907-Encephalopathy, Bovine Spongiform,
pubmed-meshheading:9204907-Glial Fibrillary Acidic Protein,
pubmed-meshheading:9204907-Glycoproteins,
pubmed-meshheading:9204907-Inflammation,
pubmed-meshheading:9204907-Macrophages,
pubmed-meshheading:9204907-Mice,
pubmed-meshheading:9204907-Mice, Inbred Strains,
pubmed-meshheading:9204907-Microglia,
pubmed-meshheading:9204907-Microscopy, Electron,
pubmed-meshheading:9204907-Molecular Chaperones,
pubmed-meshheading:9204907-PrPSc Proteins,
pubmed-meshheading:9204907-RNA,
pubmed-meshheading:9204907-Rats,
pubmed-meshheading:9204907-Rats, Sprague-Dawley,
pubmed-meshheading:9204907-Time Factors,
pubmed-meshheading:9204907-Ubiquitins,
pubmed-meshheading:9204907-Vacuoles,
pubmed-meshheading:9204907-Virulence
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pubmed:year |
1997
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pubmed:articleTitle |
Evolution of a strain of CJD that induces BSE-like plaques.
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pubmed:affiliation |
Section of Neuropathology, Yale Medical School, 310 Cedar Street, New Haven, CT 06510, USA. laura.manuelidis@yale.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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