| pubmed-article:9204893 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9204893 | lifeskim:mentions | umls-concept:C0205054 | lld:lifeskim |
| pubmed-article:9204893 | lifeskim:mentions | umls-concept:C0065110 | lld:lifeskim |
| pubmed-article:9204893 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9204893 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:9204893 | pubmed:issue | 5322 | lld:pubmed |
| pubmed-article:9204893 | pubmed:dateCreated | 1997-7-21 | lld:pubmed |
| pubmed-article:9204893 | pubmed:abstractText | Hepatocyte nuclear factors 1 and 4 (HNF-1 and HNF-4) are liver-enriched transcription factors that function in the regulation of several liver-specific genes. HNF-1 activates genes containing promoters with HNF-1 binding sites. However, this factor negatively regulates its own expression and that of other HNF-4-dependent genes that lack HNF-1 binding sites in their promoter region. This repression is exerted by a direct interaction of HNF-1 with AF2, the main activation domain of HNF-4. The dual functions of gene activation and repression suggest that HNF-1 is a global regulator of the transcriptional network involved in the maintenance of hepatocyte-specific phenotype. | lld:pubmed |
| pubmed-article:9204893 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9204893 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9204893 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9204893 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9204893 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9204893 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:9204893 | pubmed:author | pubmed-author:KtistakiEE | lld:pubmed |
| pubmed-article:9204893 | pubmed:author | pubmed-author:TalianidisII | lld:pubmed |
| pubmed-article:9204893 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9204893 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:9204893 | pubmed:volume | 277 | lld:pubmed |
| pubmed-article:9204893 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9204893 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9204893 | pubmed:pagination | 109-12 | lld:pubmed |
| pubmed-article:9204893 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:9204893 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9204893 | pubmed:articleTitle | Modulation of hepatic gene expression by hepatocyte nuclear factor 1. | lld:pubmed |
| pubmed-article:9204893 | pubmed:affiliation | Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Post Office Box 1527, 711 10 Heraklion, Crete, Greece. | lld:pubmed |
| pubmed-article:9204893 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9204893 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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