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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5322
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pubmed:dateCreated |
1997-7-21
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pubmed:abstractText |
Hepatocyte nuclear factors 1 and 4 (HNF-1 and HNF-4) are liver-enriched transcription factors that function in the regulation of several liver-specific genes. HNF-1 activates genes containing promoters with HNF-1 binding sites. However, this factor negatively regulates its own expression and that of other HNF-4-dependent genes that lack HNF-1 binding sites in their promoter region. This repression is exerted by a direct interaction of HNF-1 with AF2, the main activation domain of HNF-4. The dual functions of gene activation and repression suggest that HNF-1 is a global regulator of the transcriptional network involved in the maintenance of hepatocyte-specific phenotype.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix Leucine...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/HNF1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/HNF1B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatocyte Nuclear Factor 1,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatocyte Nuclear Factor 1-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatocyte Nuclear Factor 1-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatocyte Nuclear Factor 4,
http://linkedlifedata.com/resource/pubmed/chemical/MLX protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
277
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
109-12
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9204893-Animals,
pubmed-meshheading:9204893-Basic Helix-Loop-Helix Leucine Zipper Transcription Factors,
pubmed-meshheading:9204893-Binding Sites,
pubmed-meshheading:9204893-COS Cells,
pubmed-meshheading:9204893-DNA-Binding Proteins,
pubmed-meshheading:9204893-Gene Expression Regulation,
pubmed-meshheading:9204893-Hepatocyte Nuclear Factor 1,
pubmed-meshheading:9204893-Hepatocyte Nuclear Factor 1-alpha,
pubmed-meshheading:9204893-Hepatocyte Nuclear Factor 1-beta,
pubmed-meshheading:9204893-Hepatocyte Nuclear Factor 4,
pubmed-meshheading:9204893-Humans,
pubmed-meshheading:9204893-Liver,
pubmed-meshheading:9204893-Nuclear Proteins,
pubmed-meshheading:9204893-Phosphoproteins,
pubmed-meshheading:9204893-Promoter Regions, Genetic,
pubmed-meshheading:9204893-RNA, Messenger,
pubmed-meshheading:9204893-Recombinant Fusion Proteins,
pubmed-meshheading:9204893-Transcription Factors,
pubmed-meshheading:9204893-Transcriptional Activation,
pubmed-meshheading:9204893-Tumor Cells, Cultured
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pubmed:year |
1997
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pubmed:articleTitle |
Modulation of hepatic gene expression by hepatocyte nuclear factor 1.
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pubmed:affiliation |
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Post Office Box 1527, 711 10 Heraklion, Crete, Greece.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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