Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6636
pubmed:dateCreated
1997-7-17
pubmed:databankReference
pubmed:abstractText
The proliferation and differentiation of cells of many lineages are regulated by secreted proteins known as cytokines. Cytokines exert their biological effect through binding to cell-surface receptors that are associated with one or more members of the JAK family of cytoplasmic tyrosine kinases. Cytokine-induced receptor dimerization leads to the activation of JAKs, rapid tyrosine-phosphorylation of the cytoplasmic domains, and subsequent recruitment of various signalling proteins, including members of the STAT family of transcription factors, to the receptor complex. Using the yeast two-hybrid system, we have now isolated a new SH2-domain-containing protein, JAB, which is a JAK-binding protein that interacts with the Jak2 tyrosine-kinase JH1 domain. JAB is structurally related to CIS, a cytokine-inducible SH2 protein. Interaction of JAB with Jak1, Jak2 or Jak3 markedly reduces their tyrosine-kinase activity and suppresses the tyrosine-phosphorylation and activation of STATs. JAB and CIS appear to function as negative regulators in the JAK signalling pathway.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Erythropoietin, http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6, http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides..., http://linkedlifedata.com/resource/pubmed/chemical/JAK2 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Jak2 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Jak2 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Janus Kinase 2, http://linkedlifedata.com/resource/pubmed/chemical/Milk Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-fos, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins, http://linkedlifedata.com/resource/pubmed/chemical/SOCS1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor, http://linkedlifedata.com/resource/pubmed/chemical/STAT3 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/STAT5 Transcription Factor, http://linkedlifedata.com/resource/pubmed/chemical/Socs1 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Stat3 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Stat3 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Suppressor of Cytokine Signaling..., http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators, http://linkedlifedata.com/resource/pubmed/chemical/cytokine inducible SH2-containing...
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
26
pubmed:volume
387
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
921-4
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:9202126-Humans, pubmed-meshheading:9202126-Animals, pubmed-meshheading:9202126-Mice, pubmed-meshheading:9202126-Rats, pubmed-meshheading:9202126-Milk Proteins, pubmed-meshheading:9202126-Phosphorylation, pubmed-meshheading:9202126-Saccharomyces cerevisiae, pubmed-meshheading:9202126-Enzyme Inhibitors, pubmed-meshheading:9202126-Erythropoietin, pubmed-meshheading:9202126-Amino Acid Sequence, pubmed-meshheading:9202126-Cell Line, pubmed-meshheading:9202126-Molecular Sequence Data, pubmed-meshheading:9202126-Carrier Proteins, pubmed-meshheading:9202126-Cloning, Molecular, pubmed-meshheading:9202126-Repressor Proteins, pubmed-meshheading:9202126-Gene Expression Regulation, pubmed-meshheading:9202126-Signal Transduction, pubmed-meshheading:9202126-DNA-Binding Proteins, pubmed-meshheading:9202126-DNA, Complementary, pubmed-meshheading:9202126-Interleukin-2, pubmed-meshheading:9202126-Intracellular Signaling Peptides and Proteins, pubmed-meshheading:9202126-Interleukin-6, pubmed-meshheading:9202126-Protein-Tyrosine Kinases, pubmed-meshheading:9202126-Recombinant Fusion Proteins, pubmed-meshheading:9202126-Trans-Activators, pubmed-meshheading:9202126-Immediate-Early Proteins, pubmed-meshheading:9202126-Proto-Oncogene Proteins, pubmed-meshheading:9202126-Proto-Oncogene Proteins c-fos, pubmed-meshheading:9202126-Janus Kinase 2, pubmed-meshheading:9202126-STAT5 Transcription Factor, pubmed-meshheading:9202126-STAT3 Transcription Factor
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