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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0024348,
umls-concept:C0035820,
umls-concept:C0039194,
umls-concept:C0039195,
umls-concept:C0085236,
umls-concept:C0085358,
umls-concept:C0086418,
umls-concept:C0090425,
umls-concept:C0205345,
umls-concept:C0683598,
umls-concept:C0871261,
umls-concept:C1332714,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1440080,
umls-concept:C1704632,
umls-concept:C1706438,
umls-concept:C1706817,
umls-concept:C2698600,
umls-concept:C2911692
|
| pubmed:issue |
1
|
| pubmed:dateCreated |
1997-7-14
|
| pubmed:abstractText |
T cell-mediated cytotoxicity against Mycobacterium tuberculosis (MTB)-infected macrophages may be a major mechanism of specific host defense, but little is known about such activities in the lung. Thus, the capacity of alveolar lymphocyte MTB-specific cell lines (AL) and alveolar macrophages (AM) from tuberculin skin test-positive healthy subjects to serve as CTL and target cells, respectively, in response to MTB (H37Ra) or purified protein derivative (PPD) was investigated. Mycobacterial Ag-pulsed AM were targets of blood CTL activity at E:T ratios of > or = 30:1 (51Cr release assay), but were significantly more resistant to cytotoxicity than autologous blood monocytes. PPD- plus IL-2-expanded AL and blood lymphocytes were cytotoxic for autologous mycobacterium-stimulated monocytes at E:T ratios of > or = 10:1. The CTL activity of lymphocytes expanded with PPD was predominantly class II MHC restricted, whereas the CTL activity of lymphocytes expanded with PPD plus IL-2 was both class I and class II MHC restricted. Both CD4+ and CD8+ T cells were enriched in BL and AL expanded with PPD and IL-2, and both subsets had mycobacterium-specific CTL activity. Such novel cytotoxic responses by CD4+ and CD8+ T cells may be a major mechanism of defense against MTB at the site of disease activity.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
159
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
290-7
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9200465-Adult,
pubmed-meshheading:9200465-Antigen Presentation,
pubmed-meshheading:9200465-Antigens, Bacterial,
pubmed-meshheading:9200465-CD4-Positive T-Lymphocytes,
pubmed-meshheading:9200465-CD8-Positive T-Lymphocytes,
pubmed-meshheading:9200465-Cell Death,
pubmed-meshheading:9200465-Cells, Cultured,
pubmed-meshheading:9200465-Cytotoxicity, Immunologic,
pubmed-meshheading:9200465-Female,
pubmed-meshheading:9200465-Humans,
pubmed-meshheading:9200465-Lung,
pubmed-meshheading:9200465-Macrophages, Alveolar,
pubmed-meshheading:9200465-Male,
pubmed-meshheading:9200465-Mycobacterium tuberculosis
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Human alveolar T lymphocyte responses to Mycobacterium tuberculosis antigens: role for CD4+ and CD8+ cytotoxic T cells and relative resistance of alveolar macrophages to lysis.
|
| pubmed:affiliation |
Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|