Linked Life Data

9199790

Source:http://linkedlifedata.com/resource/pubmed/id/9199790

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-8-27
pubmed:abstractText
Phospholipids with covalently attached poly(ethylene glycol) (PEG lipids) are commonly used for the preparation of long circulating liposomes. Although it is well known that lipid/PEG-lipid mixed micelles may form above a certain critical concentration of PEG-lipid, little is known about the effects of PEG-lipids on liposome structure and leakage at submicellar concentrations. In this study we have used cryogenic transmission electron microscopy to investigate the effect of PEG(2000)-PE on aggregate structure in preparations of liposomes with different membrane compositions. The results reveal a number of important aggregate structures not documented before. The micrographs show that enclosure of PEG-PE induces the formation of open bilayer discs at concentrations well below those where mixed micelles begin to form. The maximum concentration of PEG-lipid that may be incorporated without alteration of the liposome structure depends on the phospholipid chain length, whereas phospholipid saturation or the presence of cholesterol has little or no effect. The presence of cholesterol does, however, affect the shape of the mixed micelles formed at high concentrations of PEG-lipid. Threadlike micelles form in the absence of cholesterol but adapt a globular shape when cholesterol is present.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199790-1510996, http://linkedlifedata.com/resource/pubmed/commentcorrection/9199790-1544174, http://linkedlifedata.com/resource/pubmed/commentcorrection/9199790-1586658, http://linkedlifedata.com/resource/pubmed/commentcorrection/9199790-19431813, http://linkedlifedata.com/resource/pubmed/commentcorrection/9199790-2249000, http://linkedlifedata.com/resource/pubmed/commentcorrection/9199790-2819233, http://linkedlifedata.com/resource/pubmed/commentcorrection/9199790-3043536, http://linkedlifedata.com/resource/pubmed/commentcorrection/9199790-3193246, http://linkedlifedata.com/resource/pubmed/commentcorrection/9199790-3666140, http://linkedlifedata.com/resource/pubmed/commentcorrection/9199790-3725658, http://linkedlifedata.com/resource/pubmed/commentcorrection/9199790-7077143, http://linkedlifedata.com/resource/pubmed/commentcorrection/9199790-7171607, http://linkedlifedata.com/resource/pubmed/commentcorrection/9199790-7612833, http://linkedlifedata.com/resource/pubmed/commentcorrection/9199790-7612834, http://linkedlifedata.com/resource/pubmed/commentcorrection/9199790-8242840, http://linkedlifedata.com/resource/pubmed/commentcorrection/9199790-8527843, http://linkedlifedata.com/resource/pubmed/commentcorrection/9199790-8611606
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-3495
pubmed:author
pubmed:issnType
Print
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
258-66
pubmed:dateRevised
2010-9-13
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Effect of polyethyleneglycol-phospholipids on aggregate structure in preparations of small unilamellar liposomes.
pubmed:affiliation
Department of Physical Chemistry, Uppsala University, Sweden. edwards@fki.un.se
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't