Linked Life Data

9199508

Source:http://linkedlifedata.com/resource/pubmed/id/9199508

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pubmed-article:9199508pubmed:abstractTextThe cytokine interleukin-6 (IL-6), a key mediator of immune and acute phase responses of the liver, has also been implicated in uterine functions. Estrogens are potent repressors of IL-6 production by uterine stromal cells. In the endometrial adenocarcinoma cell line Ishikawa, phorbol ester-induced activation of the IL-6 promoter was inhibited to basal levels by 17 beta-estradiol (E2) in a wild-type receptor-dependent fashion. Although tamoxifen has been shown to have estrogenic effects on the endometrium, it did not inhibit induction of the IL-6 promoter. We previously showed that inhibition of IL-6 gene expression by E2 does not involve high-affinity binding of the estrogen receptor (ER) to IL-6 DNA. We now report that the ER can directly interact with the transcription factors NF-IL6 and NF-kappa B and can inhibit their ability to bind DNA which might be the molecular basis for repression of IL-6 gene expression by estrogens.lld:pubmed
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pubmed-article:9199508pubmed:articleTitleRepression of interleukin-6 gene expression by 17 beta-estradiol: inhibition of the DNA-binding activity of the transcription factors NF-IL6 and NF-kappa B by the estrogen receptor.lld:pubmed
pubmed-article:9199508pubmed:affiliationDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.lld:pubmed
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pubmed-article:9199508pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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