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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1997-7-21
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pubmed:abstractText |
Neisseria gonorrhoeae expresses two hemin-binding proteins (HmBPs) of 97,000 and 44,000 in molecular weight. A murine monoclonal antibody (MAb) produced against the 97-kDa HmBP from N. gonorrhoeae PID543 specifically inhibited in a concentration-dependent manner the ability of hemin to promote growth. The anti-97-kDa HmBP MAb competitively inhibited binding of the 97-kDa HmBP to a hemin-agarose affinity column. In Western immunoblots, the MAb recognized the 97-kDa homologs from a limited survey of clinical gonococcal isolates. These results support the contention that the 97-kDa HmBP is involved in the gonococcal hemin acquisition pathway.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-1325963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-1371320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-1425573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-1487730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-1601981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-2126772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-2168377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-2850444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-3114148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-3126143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-388439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-6161559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-6775007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-6787066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-7103053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-7591117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-7783623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-7868605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-8005678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-8081507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-8154701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-8195069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-8300227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-8384684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-8468302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-8748023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-8755899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9199474-8945539
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0019-9567
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2970-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
|
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pubmed:year |
1997
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pubmed:articleTitle |
A monoclonal antibody directed against the 97-kilodalton gonococcal hemin-binding protein inhibits hemin utilization by Neisseria gonorrhoeae.
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pubmed:affiliation |
Department of Microbiology and Infectious Diseases, University of Calgary, Alberta, Canada. leec@acs.ucalgary.ca
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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