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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1997-7-24
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pubmed:abstractText |
Apolipoprotein E genotypes (alleles *2, *3, and *4) have been determined in 70 Aka Pygmies and 470 unrelated African sub-Saharan subjects. Allele frequencies for Pygmies are 5.7% for APOE*2, 53.6% for APOE*3, and 40.7% for APOE*4, and the global proportions for sub-Saharan subjects are 11.6% for APOE*2, 70.6% for APOE*3, and 17.8% for APOE*4. The frequencies in some ethnic groups are statistically different from the overall mean in the Afar and the Isa, the Ewe (Togo), the Malinke (Guinea), and the Mossi; three ethnic groups have a higher allele frequency of APOE*4 (Fon, 29.4%; Zairians, 33.3%; Tutsi, 38.5%). The APOE*4 allele is considered the ancestral form because of its high frequency in African Pygmies and other aboriginal populations.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0018-7143
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
575-81
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pubmed:dateRevised |
2011-4-18
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pubmed:meshHeading |
pubmed-meshheading:9198315-Africa South of the Sahara,
pubmed-meshheading:9198315-African Continental Ancestry Group,
pubmed-meshheading:9198315-Alleles,
pubmed-meshheading:9198315-Apolipoproteins E,
pubmed-meshheading:9198315-Continental Population Groups,
pubmed-meshheading:9198315-Gene Frequency,
pubmed-meshheading:9198315-Genotype,
pubmed-meshheading:9198315-Humans,
pubmed-meshheading:9198315-Oceanic Ancestry Group
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pubmed:year |
1997
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pubmed:articleTitle |
High frequency of the apolipoprotein E *4 allele in African pygmies and most of the African populations in sub-Saharan Africa.
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pubmed:affiliation |
Laboratory of Molecular Genetics, CHU Pitié-Salpêtrière, Paris, France.
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pubmed:publicationType |
Journal Article
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