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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1997-7-17
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pubmed:abstractText |
Carbon dioxide absorbents degrade sevoflurane, particularly at low gas flow rates, to fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A). Compound A causes renal proximal tubular injury in rats but has had no effect on blood urea nitrogen (BUN) or creatinine concentrations in patients. This investigation compared the effects of low-flow sevoflurane and isoflurane on renal tubular function in surgical patients using conventional (BUN and creatinine) and finer indices of renal injury, specifically those biomarkers sensitive for compound A toxicity in rats (glucosuria, proteinuria, and enzymuria [N-acetyl-beta-D-glucosaminidase (NAG) and alpha-glutathione-S-transferase (alpha GST)]).
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylglucosaminidase,
http://linkedlifedata.com/resource/pubmed/chemical/Alanine Transaminase,
http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Inhalation,
http://linkedlifedata.com/resource/pubmed/chemical/Aspartate Aminotransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Creatinine,
http://linkedlifedata.com/resource/pubmed/chemical/Ethers,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorides,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Transferase,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrocarbons, Fluorinated,
http://linkedlifedata.com/resource/pubmed/chemical/Isoflurane,
http://linkedlifedata.com/resource/pubmed/chemical/L-Lactate Dehydrogenase,
http://linkedlifedata.com/resource/pubmed/chemical/Methyl Ethers,
http://linkedlifedata.com/resource/pubmed/chemical/fluoromethyl...,
http://linkedlifedata.com/resource/pubmed/chemical/sevoflurane
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0003-3022
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1238-53
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9197292-Acetylglucosaminidase,
pubmed-meshheading:9197292-Adult,
pubmed-meshheading:9197292-Aged,
pubmed-meshheading:9197292-Alanine Transaminase,
pubmed-meshheading:9197292-Anesthesia, General,
pubmed-meshheading:9197292-Anesthetics, Inhalation,
pubmed-meshheading:9197292-Aspartate Aminotransferases,
pubmed-meshheading:9197292-Biological Markers,
pubmed-meshheading:9197292-Blood Urea Nitrogen,
pubmed-meshheading:9197292-Creatinine,
pubmed-meshheading:9197292-Ethers,
pubmed-meshheading:9197292-Female,
pubmed-meshheading:9197292-Fluorides,
pubmed-meshheading:9197292-Glutathione Transferase,
pubmed-meshheading:9197292-Humans,
pubmed-meshheading:9197292-Hydrocarbons, Fluorinated,
pubmed-meshheading:9197292-Isoflurane,
pubmed-meshheading:9197292-Kidney,
pubmed-meshheading:9197292-Kidney Tubular Necrosis, Acute,
pubmed-meshheading:9197292-L-Lactate Dehydrogenase,
pubmed-meshheading:9197292-Liver,
pubmed-meshheading:9197292-Male,
pubmed-meshheading:9197292-Methyl Ethers,
pubmed-meshheading:9197292-Middle Aged
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pubmed:year |
1997
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pubmed:articleTitle |
Assessment of low-flow sevoflurane and isoflurane effects on renal function using sensitive markers of tubular toxicity.
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pubmed:affiliation |
Department of Anesthesiology, University of Washington, Seattle 98195, USA. kharasch@u.washington.edu
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
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