Linked Life Data

9196855

Source:http://linkedlifedata.com/resource/pubmed/id/9196855

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1997-8-7
pubmed:abstractText
This study examines the effects of magnesium on vascular tone and reactivity in mesenteric resistance arteries from 17-week-old spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). Third-order branches of mesenteric arteries were mounted in a pressurized flow chamber and studied with constant flow and transmural pressure. The mesenteric arteries were perfused extra- and intra-luminally with physiological salt solution containing a normal (1.2 mmol/L), high (4.8 mmol/L), or low (0.15 mmol/L) magnesium concentration. Vascular reactivity to norepinephrine and vasopressin was examined when the agonists were applied extraluminally. High magnesium increased lumen diameter and decreased media thickness whereas low magnesium decreased lumen diameter and increased media thickness in mesenteric arteries from both SHR and WKY rats. The effects of magnesium on vascular tone were less in arteries from SHR compared with normotensive controls (p < 0.05). Low magnesium potentiated norepinephrine-induced vasoconstriction in SHR (p < 0.001) but not in WKY. Low magnesium did not modify vasopressin-induced vasoconstriction in either SHR or WKY. High magnesium attenuated vasopressin- and norepinephrine-induced vasoconstriction in SHR (p < 0.01), whereas high magnesium attenuated only norepinephrine-induced vasoconstriction in WKY (p < 0.001). These data suggest that magnesium has differential modulatory effects on vascular tone and reactivity in mesenteric resistance arteries of SHR and WKY. Magnesium may play an important role in the modulation of peripheral resistance in hypertension.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0008-4212
pubmed:author
pubmed:issnType
Print
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
293-300
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Effect of magnesium on vascular tone and reactivity in pressurized mesenteric resistance arteries from spontaneously hypertensive rats.
pubmed:affiliation
Laboratoire physiologie, pharmacologie et nutrition préventive expérimentale, UFR Médecine et Pharmacie, Université de Franche-Comte, Besançon, France.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't