| pubmed-article:9196444 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9196444 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:9196444 | lifeskim:mentions | umls-concept:C0003864 | lld:lifeskim |
| pubmed-article:9196444 | lifeskim:mentions | umls-concept:C0003873 | lld:lifeskim |
| pubmed-article:9196444 | lifeskim:mentions | umls-concept:C0029408 | lld:lifeskim |
| pubmed-article:9196444 | lifeskim:mentions | umls-concept:C0254610 | lld:lifeskim |
| pubmed-article:9196444 | lifeskim:mentions | umls-concept:C0039099 | lld:lifeskim |
| pubmed-article:9196444 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:9196444 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9196444 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:9196444 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9196444 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9196444 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9196444 | pubmed:dateCreated | 1997-7-7 | lld:pubmed |
| pubmed-article:9196444 | pubmed:abstractText | Recently, a new player in the cytokine network has been described that is produced by monocytes and can be detected in the rheumatoid synovium: interleukin-15 (IL-15). Since this cytokine may play a role in the accumulation and activation of T-cells, B-cells, and natural killer (NK) cells characteristic of synovial tissue (ST) from patients with rheumatoid arthritis (RA), the expression of IL-15 was studied in ST from RA patients in comparison with ST from patients with reactive arthritis (ReA) and osteoarthritis (OA) and the phenotype of IL-15-positive cells was determined. IL-15 expression was investigated by immunohistochemical analysis of ST from ten patients with RA, ten patients with Yersinia enterocolitica-induced ReA, and nine patients with OA. The immunohistological findings were quantified and the results obtained in the different patient groups were compared. To determine the phenotype of IL-15-expressing cells, double-labelling immunofluorescence was performed. The expression of IL-15 was significantly higher in ST from patients with RA than in ST from patients with ReA or OA. In double-label experiments, co-expression was observed with markers for macrophages, T-cells, and NK cells. The composition of the cellular infiltrate in the synovium of patients with RA might be partly explained by the specific increase in expression of IL-15 in rheumatoid ST. It can be speculated that IL-15 production by inflammatory cells other than macrophages may occur in the rheumatoid synovium. | lld:pubmed |
| pubmed-article:9196444 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9196444 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9196444 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9196444 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9196444 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9196444 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:9196444 | pubmed:issn | 0022-3417 | lld:pubmed |
| pubmed-article:9196444 | pubmed:author | pubmed-author:MeindersA EAE | lld:pubmed |
| pubmed-article:9196444 | pubmed:author | pubmed-author:GageA PAP | lld:pubmed |
| pubmed-article:9196444 | pubmed:author | pubmed-author:RaoR LRL | lld:pubmed |
| pubmed-article:9196444 | pubmed:author | pubmed-author:BreedveldF... | lld:pubmed |
| pubmed-article:9196444 | pubmed:author | pubmed-author:KluinP MPM | lld:pubmed |
| pubmed-article:9196444 | pubmed:author | pubmed-author:SmeetsT JTJ | lld:pubmed |
| pubmed-article:9196444 | pubmed:author | pubmed-author:ThurkowE WEW | lld:pubmed |
| pubmed-article:9196444 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:9196444 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9196444 | pubmed:volume | 181 | lld:pubmed |
| pubmed-article:9196444 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9196444 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9196444 | pubmed:pagination | 444-50 | lld:pubmed |
| pubmed-article:9196444 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9196444 | pubmed:meshHeading | pubmed-meshheading:9196444-... | lld:pubmed |
| pubmed-article:9196444 | pubmed:meshHeading | pubmed-meshheading:9196444-... | lld:pubmed |
| pubmed-article:9196444 | pubmed:meshHeading | pubmed-meshheading:9196444-... | lld:pubmed |
| pubmed-article:9196444 | pubmed:meshHeading | pubmed-meshheading:9196444-... | lld:pubmed |
| pubmed-article:9196444 | pubmed:meshHeading | pubmed-meshheading:9196444-... | lld:pubmed |
| pubmed-article:9196444 | pubmed:meshHeading | pubmed-meshheading:9196444-... | lld:pubmed |
| pubmed-article:9196444 | pubmed:meshHeading | pubmed-meshheading:9196444-... | lld:pubmed |
| pubmed-article:9196444 | pubmed:meshHeading | pubmed-meshheading:9196444-... | lld:pubmed |
| pubmed-article:9196444 | pubmed:meshHeading | pubmed-meshheading:9196444-... | lld:pubmed |
| pubmed-article:9196444 | pubmed:meshHeading | pubmed-meshheading:9196444-... | lld:pubmed |
| pubmed-article:9196444 | pubmed:meshHeading | pubmed-meshheading:9196444-... | lld:pubmed |
| pubmed-article:9196444 | pubmed:meshHeading | pubmed-meshheading:9196444-... | lld:pubmed |
| pubmed-article:9196444 | pubmed:meshHeading | pubmed-meshheading:9196444-... | lld:pubmed |
| pubmed-article:9196444 | pubmed:meshHeading | pubmed-meshheading:9196444-... | lld:pubmed |
| pubmed-article:9196444 | pubmed:meshHeading | pubmed-meshheading:9196444-... | lld:pubmed |
| pubmed-article:9196444 | pubmed:meshHeading | pubmed-meshheading:9196444-... | lld:pubmed |
| pubmed-article:9196444 | pubmed:meshHeading | pubmed-meshheading:9196444-... | lld:pubmed |
| pubmed-article:9196444 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9196444 | pubmed:articleTitle | Increased expression of IL-15 in the synovium of patients with rheumatoid arthritis compared with patients with Yersinia-induced arthritis and osteoarthritis. | lld:pubmed |
| pubmed-article:9196444 | pubmed:affiliation | Department of Rheumatology, Leiden University Hospital, The Netherlands. | lld:pubmed |
| pubmed-article:9196444 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9196444 | pubmed:publicationType | Comparative Study | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9196444 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9196444 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9196444 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9196444 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9196444 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9196444 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9196444 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9196444 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9196444 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9196444 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9196444 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9196444 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9196444 | lld:pubmed |
