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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1997-7-7
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pubmed:abstractText |
Recently, a new player in the cytokine network has been described that is produced by monocytes and can be detected in the rheumatoid synovium: interleukin-15 (IL-15). Since this cytokine may play a role in the accumulation and activation of T-cells, B-cells, and natural killer (NK) cells characteristic of synovial tissue (ST) from patients with rheumatoid arthritis (RA), the expression of IL-15 was studied in ST from RA patients in comparison with ST from patients with reactive arthritis (ReA) and osteoarthritis (OA) and the phenotype of IL-15-positive cells was determined. IL-15 expression was investigated by immunohistochemical analysis of ST from ten patients with RA, ten patients with Yersinia enterocolitica-induced ReA, and nine patients with OA. The immunohistological findings were quantified and the results obtained in the different patient groups were compared. To determine the phenotype of IL-15-expressing cells, double-labelling immunofluorescence was performed. The expression of IL-15 was significantly higher in ST from patients with RA than in ST from patients with ReA or OA. In double-label experiments, co-expression was observed with markers for macrophages, T-cells, and NK cells. The composition of the cellular infiltrate in the synovium of patients with RA might be partly explained by the specific increase in expression of IL-15 in rheumatoid ST. It can be speculated that IL-15 production by inflammatory cells other than macrophages may occur in the rheumatoid synovium.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-3417
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
181
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
444-50
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9196444-Adult,
pubmed-meshheading:9196444-Aged,
pubmed-meshheading:9196444-Arthritis, Reactive,
pubmed-meshheading:9196444-Arthritis, Rheumatoid,
pubmed-meshheading:9196444-Female,
pubmed-meshheading:9196444-Humans,
pubmed-meshheading:9196444-Immunoenzyme Techniques,
pubmed-meshheading:9196444-Interleukin-15,
pubmed-meshheading:9196444-Killer Cells, Natural,
pubmed-meshheading:9196444-Macrophages,
pubmed-meshheading:9196444-Male,
pubmed-meshheading:9196444-Middle Aged,
pubmed-meshheading:9196444-Osteoarthritis,
pubmed-meshheading:9196444-Synovial Membrane,
pubmed-meshheading:9196444-T-Lymphocyte Subsets,
pubmed-meshheading:9196444-Yersinia Infections,
pubmed-meshheading:9196444-Yersinia enterocolitica
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pubmed:year |
1997
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pubmed:articleTitle |
Increased expression of IL-15 in the synovium of patients with rheumatoid arthritis compared with patients with Yersinia-induced arthritis and osteoarthritis.
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pubmed:affiliation |
Department of Rheumatology, Leiden University Hospital, The Netherlands.
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pubmed:publicationType |
Journal Article,
Comparative Study
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