| pubmed-article:9196188 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9196188 | lifeskim:mentions | umls-concept:C0001175 | lld:lifeskim |
| pubmed-article:9196188 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
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| pubmed-article:9196188 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:9196188 | lifeskim:mentions | umls-concept:C0439158 | lld:lifeskim |
| pubmed-article:9196188 | lifeskim:mentions | umls-concept:C0016277 | lld:lifeskim |
| pubmed-article:9196188 | lifeskim:mentions | umls-concept:C0683278 | lld:lifeskim |
| pubmed-article:9196188 | lifeskim:mentions | umls-concept:C0332189 | lld:lifeskim |
| pubmed-article:9196188 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:9196188 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:9196188 | lifeskim:mentions | umls-concept:C2003942 | lld:lifeskim |
| pubmed-article:9196188 | lifeskim:mentions | umls-concept:C0449435 | lld:lifeskim |
| pubmed-article:9196188 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:9196188 | pubmed:dateCreated | 1997-8-5 | lld:pubmed |
| pubmed-article:9196188 | pubmed:abstractText | Five Candida albicans colonies from each infection in AIDS patients receiving fluconazole therapy for oropharyngeal candidiasis over a 2-year period were evaluated by antifungal susceptibility testing and DNA subtyping, and the results were correlated with clinical response to determine the occurrence of clinically significant selection of more-resistant C. albicans over multiple infections. A total of 534 C. albicans isolates were obtained from 38 patients who exhibited 84 episodes of infection. Antifungal susceptibility testing revealed that the MICs for 93% of the isolates were < or = 8.0 microg/ml and the MICs for 7% of the isolates were > or = 64 microg/ml. DNA subtyping revealed 70 different subtypes, with 78% of patients with one infection exhibiting one DNA subtype and 80% of patients with more than one infection exhibiting multiple DNA subtypes. Also, patients who had multiple infections had lower CD4 counts than those with single infections. Differences between the single-infection group and the multiple-infection group regarding the number of DNA subtypes and CD4 counts were both statistically significant. Of the 74 evaluable infections all were successfully treated with regular-dose (100-mg/day) fluconazole, except for three patients who ultimately responded to higher-dose fluconazole. Only one patient may have shown clinically significant selection of a more-resistant C. albicans strain over multiple courses of treatment. Interestingly, MICs reached only 8.0 microg/ml, even though doses of 400 mg of fluconazole were necessary for clinical cure. | lld:pubmed |
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| pubmed-article:9196188 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9196188 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9196188 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9196188 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9196188 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9196188 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9196188 | pubmed:issn | 0095-1137 | lld:pubmed |
| pubmed-article:9196188 | pubmed:author | pubmed-author:SmithJ AJA | lld:pubmed |
| pubmed-article:9196188 | pubmed:author | pubmed-author:ReddingS WSW | lld:pubmed |
| pubmed-article:9196188 | pubmed:author | pubmed-author:RinaldiM GMG | lld:pubmed |
| pubmed-article:9196188 | pubmed:author | pubmed-author:PfallerM AMA | lld:pubmed |
| pubmed-article:9196188 | pubmed:author | pubmed-author:ProwsJJ | lld:pubmed |
| pubmed-article:9196188 | pubmed:author | pubmed-author:FothergillA... | lld:pubmed |
| pubmed-article:9196188 | pubmed:author | pubmed-author:MesserS ASA | lld:pubmed |
| pubmed-article:9196188 | pubmed:author | pubmed-author:BradleyL LLL | lld:pubmed |
| pubmed-article:9196188 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9196188 | pubmed:volume | 35 | lld:pubmed |
| pubmed-article:9196188 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9196188 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9196188 | pubmed:pagination | 1761-5 | lld:pubmed |
| pubmed-article:9196188 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:9196188 | pubmed:meshHeading | pubmed-meshheading:9196188-... | lld:pubmed |
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| pubmed-article:9196188 | pubmed:meshHeading | pubmed-meshheading:9196188-... | lld:pubmed |
| pubmed-article:9196188 | pubmed:meshHeading | pubmed-meshheading:9196188-... | lld:pubmed |
| pubmed-article:9196188 | pubmed:meshHeading | pubmed-meshheading:9196188-... | lld:pubmed |
| pubmed-article:9196188 | pubmed:meshHeading | pubmed-meshheading:9196188-... | lld:pubmed |
| pubmed-article:9196188 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9196188 | pubmed:articleTitle | Variations in fluconazole susceptibility and DNA subtyping of multiple Candida albicans colonies from patients with AIDS and oral candidiasis suffering one or more episodes of infection. | lld:pubmed |
| pubmed-article:9196188 | pubmed:affiliation | Department of General Dentistry, University of Texas Health Science Center, San Antonio 78284, USA. | lld:pubmed |
| pubmed-article:9196188 | pubmed:publicationType | Journal Article | lld:pubmed |
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