Linked Life Data

9196188

Source:http://linkedlifedata.com/resource/pubmed/id/9196188

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1997-8-5
pubmed:abstractText
Five Candida albicans colonies from each infection in AIDS patients receiving fluconazole therapy for oropharyngeal candidiasis over a 2-year period were evaluated by antifungal susceptibility testing and DNA subtyping, and the results were correlated with clinical response to determine the occurrence of clinically significant selection of more-resistant C. albicans over multiple infections. A total of 534 C. albicans isolates were obtained from 38 patients who exhibited 84 episodes of infection. Antifungal susceptibility testing revealed that the MICs for 93% of the isolates were < or = 8.0 microg/ml and the MICs for 7% of the isolates were > or = 64 microg/ml. DNA subtyping revealed 70 different subtypes, with 78% of patients with one infection exhibiting one DNA subtype and 80% of patients with more than one infection exhibiting multiple DNA subtypes. Also, patients who had multiple infections had lower CD4 counts than those with single infections. Differences between the single-infection group and the multiple-infection group regarding the number of DNA subtypes and CD4 counts were both statistically significant. Of the 74 evaluable infections all were successfully treated with regular-dose (100-mg/day) fluconazole, except for three patients who ultimately responded to higher-dose fluconazole. Only one patient may have shown clinically significant selection of a more-resistant C. albicans strain over multiple courses of treatment. Interestingly, MICs reached only 8.0 microg/ml, even though doses of 400 mg of fluconazole were necessary for clinical cure.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9196188-1572980, http://linkedlifedata.com/resource/pubmed/commentcorrection/9196188-1973698, http://linkedlifedata.com/resource/pubmed/commentcorrection/9196188-3068254, http://linkedlifedata.com/resource/pubmed/commentcorrection/9196188-7751360, http://linkedlifedata.com/resource/pubmed/commentcorrection/9196188-7903316, http://linkedlifedata.com/resource/pubmed/commentcorrection/9196188-7907345, http://linkedlifedata.com/resource/pubmed/commentcorrection/9196188-7929752, http://linkedlifedata.com/resource/pubmed/commentcorrection/9196188-7942935, http://linkedlifedata.com/resource/pubmed/commentcorrection/9196188-8027327, http://linkedlifedata.com/resource/pubmed/commentcorrection/9196188-8027353, http://linkedlifedata.com/resource/pubmed/commentcorrection/9196188-8060555, http://linkedlifedata.com/resource/pubmed/commentcorrection/9196188-8150956, http://linkedlifedata.com/resource/pubmed/commentcorrection/9196188-8150963, http://linkedlifedata.com/resource/pubmed/commentcorrection/9196188-8161633, http://linkedlifedata.com/resource/pubmed/commentcorrection/9196188-8815082
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0095-1137
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1761-5
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Variations in fluconazole susceptibility and DNA subtyping of multiple Candida albicans colonies from patients with AIDS and oral candidiasis suffering one or more episodes of infection.
pubmed:affiliation
Department of General Dentistry, University of Texas Health Science Center, San Antonio 78284, USA.
pubmed:publicationType
Journal Article