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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1997-7-21
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pubmed:abstractText |
In a search for early lymphoid-specific genes, we isolated a cDNA clone (LL7) encoding a murine homologue of Ki-67 protein, a proliferation-related nuclear antigen. LL7 transcript appears preferentially in lymphoid organs as the bone marrow, spleen, and the thymus. Here, we studied the expression of murine Ki-67 (mKi-67) mRNA among various organs or tissues during the early development of fetus. In fetus, mKi-67 mRNA appears developmentally as early as day 11 and is expressed maximally at day 15. In situ hybridization on the section revealed that the expression of mKi-67 mRNA is preferential in the area of active organ formation such as neurological system and the fetal liver. These results suggest that mKi-67 plays an important role in the proliferation of early embryonic precursor cells of neurological and immune systems.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
235
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
191-6
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9196061-Animals,
pubmed-meshheading:9196061-B-Cell-Specific Activator Protein,
pubmed-meshheading:9196061-Blotting, Northern,
pubmed-meshheading:9196061-Brain,
pubmed-meshheading:9196061-Cell Differentiation,
pubmed-meshheading:9196061-Cells, Cultured,
pubmed-meshheading:9196061-DNA-Binding Proteins,
pubmed-meshheading:9196061-Embryo, Mammalian,
pubmed-meshheading:9196061-Embryonic and Fetal Development,
pubmed-meshheading:9196061-Gene Expression Regulation, Developmental,
pubmed-meshheading:9196061-In Situ Hybridization,
pubmed-meshheading:9196061-Ki-67 Antigen,
pubmed-meshheading:9196061-Liver,
pubmed-meshheading:9196061-Lymphoid Tissue,
pubmed-meshheading:9196061-Mice,
pubmed-meshheading:9196061-Mice, Inbred BALB C,
pubmed-meshheading:9196061-Nuclear Proteins,
pubmed-meshheading:9196061-RNA, Messenger,
pubmed-meshheading:9196061-Stem Cells,
pubmed-meshheading:9196061-Transcription, Genetic,
pubmed-meshheading:9196061-Transcription Factors
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pubmed:year |
1997
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pubmed:articleTitle |
Expression of the proliferation-related Ki-67 mRNA in the early development of murine embryo.
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pubmed:affiliation |
Department of Immunology, Kumamoto University School of Medicine, Honjo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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