|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1997-7-28
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
The rho family of small G proteins, including rho, rac and cdc42, are involved in many cellular processes, including cell transformation by ras and the organization of the actin cytoskeleton. Additionally, rac has a role in the regulation of phagocyte NADPH oxidase. Guanine nucleotide dissociation inhibitors (GDIs) of the rhoGDI family bind to these G proteins and regulate their activity by preventing nucleotide dissociation and by controlling their interaction with membranes.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0969-2126
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
5
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
623-33
|
|
pubmed:dateRevised |
2009-9-29
|
|
pubmed:meshHeading |
pubmed-meshheading:9195882-Amino Acid Sequence,
pubmed-meshheading:9195882-Crystallography, X-Ray,
pubmed-meshheading:9195882-GTP-Binding Proteins,
pubmed-meshheading:9195882-Guanine Nucleotide Dissociation Inhibitors,
pubmed-meshheading:9195882-Models, Molecular,
pubmed-meshheading:9195882-Molecular Sequence Data,
pubmed-meshheading:9195882-Protein Binding,
pubmed-meshheading:9195882-Protein Conformation,
pubmed-meshheading:9195882-Protein Folding,
pubmed-meshheading:9195882-Protein Prenylation,
pubmed-meshheading:9195882-Sequence Alignment,
pubmed-meshheading:9195882-Sequence Homology, Amino Acid
|
|
pubmed:year |
1997
|
|
pubmed:articleTitle |
A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm.
|
|
pubmed:affiliation |
Department of Medicine, University College London, Rayne Institute, 5 University Street, London, WC1E 6JJ, UK.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
