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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1997-7-31
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pubmed:abstractText |
First described in 1959, medullary thyroid carcinoma (MTC) arises from parafollicular C cells distributed throughout the thyroid, and may occur in one of two clinical forms, sporadic (80%) or familial. Familial MTC may present as a palpable thyroid nodule, but may also be diagnosed by screening relatives of an index case for a raised basal serum calcitonin or a rise in calcitonin following a stimulated pentagastric test. Both tests are highly sensitive for C-cell hyperplasia and MTC. Sporadic cases of MTC most commonly present as asymptomatic thyroid nodules with normal thyroid function tests. In this note, the history of a patient is presented in which a sporadic MTC was associated with goitre and both symptoms and biochemical evidence of thyrotoxicosis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0035-8835
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
199-200
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:9195818-Adult,
pubmed-meshheading:9195818-Calcitonin,
pubmed-meshheading:9195818-Carcinoma, Medullary,
pubmed-meshheading:9195818-Follow-Up Studies,
pubmed-meshheading:9195818-Goiter, Nodular,
pubmed-meshheading:9195818-Humans,
pubmed-meshheading:9195818-Hyperplasia,
pubmed-meshheading:9195818-Male,
pubmed-meshheading:9195818-Thyroid Gland,
pubmed-meshheading:9195818-Thyroid Neoplasms,
pubmed-meshheading:9195818-Thyroid Nodule,
pubmed-meshheading:9195818-Thyroidectomy,
pubmed-meshheading:9195818-Thyrotoxicosis
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pubmed:year |
1997
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pubmed:articleTitle |
Sporadic medullary thyroid carcinoma associated with toxic multinodular goitre.
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pubmed:affiliation |
Department of Surgery, Ninewells Hospital and Medical School, Dundee, UK.
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pubmed:publicationType |
Journal Article,
Case Reports
|