Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
25
|
| pubmed:dateCreated |
1997-7-17
|
| pubmed:abstractText |
In an attempt to study the mechanisms by which estrogens affect vascular responses, we utilized aortic preparations from intact and ovariectomized female rats receiving low- and high-dose subcutaneous estrogen treatments. Oil-treated, as well as male rats, served as controls. In ovariectomized females, low-dose 17-beta-estradiol injections (5 microg/kg daily for two days) affected the basal release of nitric oxide, as evaluated by concentration-related curves to superoxide dismutase and N(G)-Methyl-L-arginine acetate, which was found to be greater in 17-beta-estradiol-treated females compared to oil-treated females or males. Conversely, the nitric oxide-related vascular relaxation evoked by acetylcholine and sodium nitroprusside was unchanged. Prostacyclin production was also evaluated. Aortic rings from ovariectomized 17-beta-estradiol-treated females released significantly more prostacyclin than those from oil-treated females. These results point out a possible role for nitric oxide and prostacyclin in the vascular protection brought about by physiological levels of estrogens. When intact females were treated with high doses of ethynilestradiol (100 microg/Kg daily for one month), a component of contraceptive pills, either the basal release of nitric oxide, or acetylcholine-induced relaxation underwent a significant decrease. Likewise, the relaxant responses to sodium nitroprusside were impaired in the aortic rings obtained from ethynilestradiol-treated animals when compared to controls. Similarly, the amount of prostacyclin released from aortic tissues obtained from ethynilestradiol-treated animals was significantly reduced. These results may provide a possible explanation for the higher incidence of cardiovascular disease in women who take contraceptive preparations containing high doses of estrogens.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Epoprostenol,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol Congeners,
http://linkedlifedata.com/resource/pubmed/chemical/Ethinyl Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroprusside,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase,
http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents,
http://linkedlifedata.com/resource/pubmed/chemical/omega-N-Methylarginine
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0024-3205
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
60
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2291-302
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9194684-Acetylcholine,
pubmed-meshheading:9194684-Animals,
pubmed-meshheading:9194684-Aorta,
pubmed-meshheading:9194684-Dose-Response Relationship, Drug,
pubmed-meshheading:9194684-Drug Interactions,
pubmed-meshheading:9194684-Enzyme Inhibitors,
pubmed-meshheading:9194684-Epoprostenol,
pubmed-meshheading:9194684-Estradiol,
pubmed-meshheading:9194684-Estradiol Congeners,
pubmed-meshheading:9194684-Ethinyl Estradiol,
pubmed-meshheading:9194684-Female,
pubmed-meshheading:9194684-Male,
pubmed-meshheading:9194684-Muscle, Smooth, Vascular,
pubmed-meshheading:9194684-Muscle Contraction,
pubmed-meshheading:9194684-Nitric Oxide,
pubmed-meshheading:9194684-Nitroprusside,
pubmed-meshheading:9194684-Norepinephrine,
pubmed-meshheading:9194684-Ovariectomy,
pubmed-meshheading:9194684-Rats,
pubmed-meshheading:9194684-Rats, Sprague-Dawley,
pubmed-meshheading:9194684-Superoxide Dismutase,
pubmed-meshheading:9194684-Vasodilator Agents,
pubmed-meshheading:9194684-omega-N-Methylarginine
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Differential effects of low- and high-dose estrogen treatments on vascular responses in female rats.
|
| pubmed:affiliation |
Institute of Pharmacological Sciences, University of Milan, Italy.
|
| pubmed:publicationType |
Journal Article,
In Vitro
|