| pubmed-article:9192769 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9192769 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9192769 | lifeskim:mentions | umls-concept:C0282552 | lld:lifeskim |
| pubmed-article:9192769 | lifeskim:mentions | umls-concept:C0524914 | lld:lifeskim |
| pubmed-article:9192769 | lifeskim:mentions | umls-concept:C0006556 | lld:lifeskim |
| pubmed-article:9192769 | lifeskim:mentions | umls-concept:C0009017 | lld:lifeskim |
| pubmed-article:9192769 | lifeskim:mentions | umls-concept:C0679058 | lld:lifeskim |
| pubmed-article:9192769 | lifeskim:mentions | umls-concept:C1547699 | lld:lifeskim |
| pubmed-article:9192769 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:9192769 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:9192769 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:9192769 | lifeskim:mentions | umls-concept:C2697616 | lld:lifeskim |
| pubmed-article:9192769 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:9192769 | pubmed:dateCreated | 1997-7-10 | lld:pubmed |
| pubmed-article:9192769 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9192769 | pubmed:abstractText | Chemokines refer to a rapidly expanding family of small cytokines whose primary function is recruitment of leukocytes to inflammatory sites. These are known to bind to seven-transmembrane-domain containing receptors. A cDNA clone, CHEMR1, resembling the typical G protein-coupled receptor, was isolated from a mouse cytotoxic T-lymphocyte (CTL) library. Northern blot analysis in mouse cell lines suggests that its expression is found in a variety of cells, including T cells, B cells, and macrophages. The CHEMR1 gene Scya3r2 is a single-copy gene whose open reading frame may be in a single exon and maps to the distal region of mouse Chr 9 where the mouse macrophage inflammatory protein-1alpha (MIP-1alpha) receptor gene Scya3r and two related C-C chemokine receptor-like genes reside. Amino acid sequence comparison shows that CHEMR1 is 84% identical to human CCR-4, indicating that CHEMR1 is likely to be a mouse CCR-4. Binding assays using 125I-labeled C-C chemokines in mammalian cells indicated that CHEMR1 did not bind MIP-1alpha, RANTES, or MIP-1beta, whereas CCR-1 binds MIP-1alpha and RANTES. Our result is different from the reported properties of human CCR-4. This suggests that CHEMR1 may be a receptor for unidentified C-C chemokine or a low-affinity receptor for MIP-1alpha. | lld:pubmed |
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| pubmed-article:9192769 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9192769 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:9192769 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9192769 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9192769 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:9192769 | pubmed:author | pubmed-author:KozakC ACA | lld:pubmed |
| pubmed-article:9192769 | pubmed:author | pubmed-author:MOER ERE | lld:pubmed |
| pubmed-article:9192769 | pubmed:author | pubmed-author:KwonB SBS | lld:pubmed |
| pubmed-article:9192769 | pubmed:author | pubmed-author:JoMM | lld:pubmed |
| pubmed-article:9192769 | pubmed:author | pubmed-author:TaubD DDD | lld:pubmed |
| pubmed-article:9192769 | pubmed:author | pubmed-author:YounB SBS | lld:pubmed |
| pubmed-article:9192769 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9192769 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9192769 | pubmed:volume | 89 | lld:pubmed |
| pubmed-article:9192769 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9192769 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9192769 | pubmed:pagination | 4448-60 | lld:pubmed |
| pubmed-article:9192769 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:9192769 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9192769 | pubmed:articleTitle | Molecular cloning and characterization of a cDNA, CHEMR1, encoding a chemokine receptor with a homology to the human C-C chemokine receptor, CCR-4. | lld:pubmed |
| pubmed-article:9192769 | pubmed:affiliation | Department of Microbiology and Immunology, and Walther Oncology Center, Indiana University School of Medicine, Indianapolis 46202-5120, USA. | lld:pubmed |
| pubmed-article:9192769 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9192769 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:9192769 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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