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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1997-7-7
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pubmed:abstractText |
B7 ligands on APCs engage CD28/CTLA4 counter-receptors on T cells critical for T lymphocyte activation and functional differentiation of T helper subsets. To examine whether the ligands B7-1 (CD80) and B7-2 (CD86) affect gene expression of Th2 cytokines and development of Th2-mediated pathologic tissue reactions, mice were treated with anti-B7-1 or anti-B7-2 at the time of sensitization to footpad inoculation of Schistosoma mansoni eggs or induction of pulmonary granuloma by i.v. injected eggs. Anti-B7-2 treatment inhibited pulmonary granuloma formation by 74% and decreased levels of lung IL-5 and IL-13 transcripts compared with those in animals given control Ig by 20- and 5-fold, respectively, while anti-B7-1 administration has no effect. Anti-B7-2 treatment blocked CD4 cell gene expression of IL-4, IL-5, and IL-13, but had no effect on IFN-gamma or IL-10 in animals inoculated with S. mansoni ova, larvae from the filarial helminth Brugia malayi, or CFA. Anti-B7-1 administration had no effect on CD4 cell transcript levels of IL-4 and IL-5, but inhibited IFN-gamma in mice inoculated with ova. Similar effects of anti-B7-2 on CD4 cell cytokine expression were observed in IL-4 knockout mice, indicating the existence of an alternative pathway for induction and/or expression of these cytokine genes. These findings suggest a possible role for anti-B7-2 in the therapy of infectious and atopic diseases in which immunopathologic reactions are mediated by selected Th2 cytokines.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD86,
http://linkedlifedata.com/resource/pubmed/chemical/Cd86 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-13,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-5,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
158
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5914-20
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9190944-Animals,
pubmed-meshheading:9190944-Antibodies, Monoclonal,
pubmed-meshheading:9190944-Antigen-Presenting Cells,
pubmed-meshheading:9190944-Antigens, CD,
pubmed-meshheading:9190944-Antigens, CD28,
pubmed-meshheading:9190944-Antigens, CD4,
pubmed-meshheading:9190944-Antigens, CD80,
pubmed-meshheading:9190944-Antigens, CD86,
pubmed-meshheading:9190944-Cytokines,
pubmed-meshheading:9190944-Female,
pubmed-meshheading:9190944-Granuloma,
pubmed-meshheading:9190944-Interferon-gamma,
pubmed-meshheading:9190944-Interleukin-13,
pubmed-meshheading:9190944-Interleukin-4,
pubmed-meshheading:9190944-Interleukin-5,
pubmed-meshheading:9190944-Lung Diseases, Parasitic,
pubmed-meshheading:9190944-Membrane Glycoproteins,
pubmed-meshheading:9190944-Mice,
pubmed-meshheading:9190944-Mice, Inbred C57BL,
pubmed-meshheading:9190944-Schistosomiasis,
pubmed-meshheading:9190944-Th2 Cells,
pubmed-meshheading:9190944-Transcription, Genetic
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pubmed:year |
1997
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pubmed:articleTitle |
B7-2 requirement for helminth-induced granuloma formation and CD4 type 2 T helper cell cytokine expression.
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pubmed:affiliation |
Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
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pubmed:publicationType |
Journal Article
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