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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
20
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pubmed:dateCreated |
1997-6-19
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pubmed:abstractText |
The aim of this follow-up study was to assess whether slightly elevated urinary albumin excretion, i.e., microalbuminuria, precedes development of atherosclerotic vascular disease in IDDM. Out of 259 IDDM-patients 30 developed vascular disease during 2,457 person-years. Microalbuminuria was significantly predictive of vascular disease (hazard ratio (95% confidence interval) 1.06 (1.02-1.18) per 5 mg/24 hours increase in urinary albumin excretion; p = 0.002). The predictive effect was independent of age, sex, blood pressure, tobacco smoking, serum concentrations of total-cholesterol, HDL-cholesterol, sialic acid, and von Willebrand factor, and of haemoglobin A1c, insulin dose, diabetes duration, and diabetic nephropathy (hazard ratio (95% confidence interval) 1.04 (1.01-1.08) per 5 mg/24 hours increase in urinary albumin excretion; p = 0.03). It is concluded that slightly elevated urinary albumin excretion is an independent predictor of atherosclerotic vascular disease in insulin-dependent diabetes mellitus.
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pubmed:language |
dan
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0041-5782
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
159
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3010-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9190730-Adult,
pubmed-meshheading:9190730-Albuminuria,
pubmed-meshheading:9190730-Arteriosclerosis,
pubmed-meshheading:9190730-Cohort Studies,
pubmed-meshheading:9190730-Diabetes Mellitus, Type 1,
pubmed-meshheading:9190730-Diabetic Angiopathies,
pubmed-meshheading:9190730-Female,
pubmed-meshheading:9190730-Follow-Up Studies,
pubmed-meshheading:9190730-Humans,
pubmed-meshheading:9190730-Male,
pubmed-meshheading:9190730-Prognosis
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pubmed:year |
1997
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pubmed:articleTitle |
[Microalbuminuria as predictor of atherosclerotic cardiovascular disease in IDDM].
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pubmed:affiliation |
Steno Diabetes Center, Gentofte.
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pubmed:publicationType |
Journal Article,
English Abstract,
Research Support, Non-U.S. Gov't
|