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rdf:type |
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lifeskim:mentions |
umls-concept:C0017282,
umls-concept:C0019704,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0035696,
umls-concept:C0040715,
umls-concept:C0064771,
umls-concept:C0599718,
umls-concept:C0599813,
umls-concept:C0599893,
umls-concept:C0887840,
umls-concept:C1522702,
umls-concept:C1999216
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pubmed:issue |
2
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pubmed:dateCreated |
1997-6-16
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pubmed:abstractText |
The human immunodeficiency virus type 1 (HIV-1) regulatory protein Rev is required for unspliced and incompletely spliced viral mRNAs to appear in the cytoplasm and thus for viral replication. Translocation of Rev from the nucleus to the cytoplasm is essential if Rev is to function. We wanted to identify inhibitors of this transport process because they would be potential antiviral agents.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibiotics, Antineoplastic,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Unsaturated,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, rev,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/leptomycin B,
http://linkedlifedata.com/resource/pubmed/chemical/rev Gene Products, Human...
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1074-5521
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
139-47
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9190288-Alternative Splicing,
pubmed-meshheading:9190288-Animals,
pubmed-meshheading:9190288-Antibiotics, Antineoplastic,
pubmed-meshheading:9190288-Biological Transport,
pubmed-meshheading:9190288-COS Cells,
pubmed-meshheading:9190288-Cytoplasm,
pubmed-meshheading:9190288-Fatty Acids, Unsaturated,
pubmed-meshheading:9190288-Gene Expression Regulation, Viral,
pubmed-meshheading:9190288-Gene Products, rev,
pubmed-meshheading:9190288-HIV-1,
pubmed-meshheading:9190288-Humans,
pubmed-meshheading:9190288-Monocytes,
pubmed-meshheading:9190288-RNA, Messenger,
pubmed-meshheading:9190288-rev Gene Products, Human Immunodeficiency Virus
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pubmed:year |
1997
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pubmed:articleTitle |
Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA.
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pubmed:affiliation |
Sandoz Research Institute, Brunner Strasse 59, A1230 Vienna, Austria. wolff_b@a1.wienv1.sandoz.com
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pubmed:publicationType |
Journal Article
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