Linked Life Data

9189174

Source:http://linkedlifedata.com/resource/pubmed/id/9189174

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1997-7-3
pubmed:abstractText
This study determined the effects of the 5-hydroxytryptamine (5-HT) serotonin antagonists ondansetron and (3 alpha-tropanyl]-1H-indole-3-carboxylic acid ester HCl (ICS 205-930) on hypothermia induced in rats by irradiation and by administration of a 5-HT3 receptor agonist, 2-methyl-5-hydroxytryptamine (2-Me-5-HT). Intraperitoneal (i.p.) administration of 50-200 micrograms/kg of ondansetron and intraventricular administration of 5-20 micrograms of ondansetron attenuated hypothermia induced by 20 Gy gamma rays. However, the same doses of ondansetron administered i.p. or intraventricularly did not antagonize the hypothermia induced by 10 micrograms 2-Me-5-HT. In contrast, i.p. administration of 50-200 micrograms/kg of ICS 205-930 and intraventricular administration of 5-20 micrograms of ICS 205-930 attenuated hypothermia induced by radiation and 2-Me-5-HT. These results indicate that ICS 205-930 attenuates hypothermia induced by radiation and 2-Me-5-HT. However, the doses of ondansetron that attenuated radiation-induced hypothermia did not attenuate hypothermia induced by 2-Me-5-HT.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0033-7587
pubmed:author
pubmed:issnType
Print
pubmed:volume
147
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
741-6
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Effect of ondansetron and ICS 205-930 on radiation-induced hypothermia in rats.
pubmed:affiliation
Radiation Pathophysiology and Toxicology Department, Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20889-5603, USA.
pubmed:publicationType
Journal Article