Linked Life Data

9185110

Source:http://linkedlifedata.com/resource/pubmed/id/9185110

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1997-7-24
pubmed:abstractText
Chronic edema of the arm (postmastectomy edema, PME) is a common and incurable complication of breast cancer treatment, often developing without warning months or years later. Although the original cause of PME is damage to axillary lymph drainage routes by surgery and radiotherapy, many observations suggest that additional factors are involved. Recent attention has focused on the Starling forces in the skin and subcutis in PME. An important finding was that the protein concentration, and hence colloid osmotic pressure, of the subcutaneous interstitial fluid of the PMF arm is unexpectedly lower than in the unaffected arm, correlating negatively with the degree of swelling. There are several possible explanations for this, such as a rise in capillary filtration rate, or interstitial proteolysis. A systemic component to PME is suggested by the finding of a lower plasma protein concentration in affected women compared with a matched postmastectomy group without swelling. A recent study using intra-vital capillaroscopy has indicated that angiogenesis occurs in the skin in PME, and an increased capillary surface area for filtration could result in an increased fluid load on a compromised lymph drainage system. Further elucidation of the pathophysiological processes in PME, in particular the adjustments to Starling forces, will enable more effective therapy of this distressing condition.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0098-6577
pubmed:author
pubmed:issnType
Print
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S76-81
pubmed:dateRevised
2010-8-25
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Chronic arm edema following breast cancer treatment.
pubmed:affiliation
Department of Medicine, St George's Hospital Medical School, London, England, United Kingdom.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't