pubmed-article:9182678 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:9182678 | lifeskim:mentions | umls-concept:C0026339 | lld:lifeskim |
pubmed-article:9182678 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
pubmed-article:9182678 | lifeskim:mentions | umls-concept:C0014257 | lld:lifeskim |
pubmed-article:9182678 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
pubmed-article:9182678 | lifeskim:mentions | umls-concept:C0003483 | lld:lifeskim |
pubmed-article:9182678 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
pubmed-article:9182678 | lifeskim:mentions | umls-concept:C1801960 | lld:lifeskim |
pubmed-article:9182678 | lifeskim:mentions | umls-concept:C0001511 | lld:lifeskim |
pubmed-article:9182678 | lifeskim:mentions | umls-concept:C1563937 | lld:lifeskim |
pubmed-article:9182678 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
pubmed-article:9182678 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
pubmed-article:9182678 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
pubmed-article:9182678 | pubmed:issue | 12 | lld:pubmed |
pubmed-article:9182678 | pubmed:dateCreated | 1997-7-17 | lld:pubmed |
pubmed-article:9182678 | pubmed:abstractText | Adhesion of monocytes to the endothelium in lesion-prone areas is one of the earliest events in fatty streak formation leading to atherogenesis. The molecular basis of increased monocyte adhesion is not fully characterized. We have identified a novel vascular monocyte adhesion-associated protein, VMAP-1, that plays a role in adhesion of monocytes to activated endothelium. Originally selected for its ability to block binding of a mouse monocyte-like cell line (WEHI78/24) to cytokine- or LPS-stimulated cultured mouse endothelial cells in vitro, antiVMAP-1 mAb LM151 cross-reacts with rabbit endothelium and blocks binding of human monocytes to cultured rabbit aortic endothelial cells stimulated with minimally modified low density lipoprotein, thought to be a physiologically relevant atherogenic stimulus. Most importantly, LM151 prevents adhesion of normal monocytes and monocytoid cells to intact aortic endothelium from cholesterol-fed rabbits in an ex vivo assay. VMAP-1 is a 50-kD protein. Immunohistology of vessels reveals focal constitutive expression in aorta and other large vessels. VMAP-1 is thus a novel vascular adhesion-associated protein that appears to play a critical role in monocyte adhesion to aortic endothelial cells in atherogenesis in vivo. | lld:pubmed |
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pubmed-article:9182678 | pubmed:language | eng | lld:pubmed |
pubmed-article:9182678 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9182678 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:9182678 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:9182678 | pubmed:month | Jun | lld:pubmed |
pubmed-article:9182678 | pubmed:issn | 0022-1007 | lld:pubmed |
pubmed-article:9182678 | pubmed:author | pubmed-author:ButcherE CEC | lld:pubmed |
pubmed-article:9182678 | pubmed:author | pubmed-author:CookeJ PJP | lld:pubmed |
pubmed-article:9182678 | pubmed:author | pubmed-author:BerlinerJ AJA | lld:pubmed |
pubmed-article:9182678 | pubmed:author | pubmed-author:SuhBB | lld:pubmed |
pubmed-article:9182678 | pubmed:author | pubmed-author:TsaiP YPY | lld:pubmed |
pubmed-article:9182678 | pubmed:author | pubmed-author:McEvoyL MLM | lld:pubmed |
pubmed-article:9182678 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:9182678 | pubmed:day | 16 | lld:pubmed |
pubmed-article:9182678 | pubmed:volume | 185 | lld:pubmed |
pubmed-article:9182678 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:9182678 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:9182678 | pubmed:pagination | 2069-77 | lld:pubmed |
pubmed-article:9182678 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:9182678 | pubmed:year | 1997 | lld:pubmed |
pubmed-article:9182678 | pubmed:articleTitle | Novel vascular molecule involved in monocyte adhesion to aortic endothelium in models of atherogenesis. | lld:pubmed |
pubmed-article:9182678 | pubmed:affiliation | Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University, Stanford, California 94305, USA. | lld:pubmed |
pubmed-article:9182678 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:9182678 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:9182678 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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