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rdf:type |
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lifeskim:mentions |
umls-concept:C0001511,
umls-concept:C0003483,
umls-concept:C0014257,
umls-concept:C0026336,
umls-concept:C0026339,
umls-concept:C0026473,
umls-concept:C0205314,
umls-concept:C0567416,
umls-concept:C0679622,
umls-concept:C1314939,
umls-concept:C1563937,
umls-concept:C1801960
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pubmed:issue |
12
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pubmed:dateCreated |
1997-7-17
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pubmed:abstractText |
Adhesion of monocytes to the endothelium in lesion-prone areas is one of the earliest events in fatty streak formation leading to atherogenesis. The molecular basis of increased monocyte adhesion is not fully characterized. We have identified a novel vascular monocyte adhesion-associated protein, VMAP-1, that plays a role in adhesion of monocytes to activated endothelium. Originally selected for its ability to block binding of a mouse monocyte-like cell line (WEHI78/24) to cytokine- or LPS-stimulated cultured mouse endothelial cells in vitro, antiVMAP-1 mAb LM151 cross-reacts with rabbit endothelium and blocks binding of human monocytes to cultured rabbit aortic endothelial cells stimulated with minimally modified low density lipoprotein, thought to be a physiologically relevant atherogenic stimulus. Most importantly, LM151 prevents adhesion of normal monocytes and monocytoid cells to intact aortic endothelium from cholesterol-fed rabbits in an ex vivo assay. VMAP-1 is a 50-kD protein. Immunohistology of vessels reveals focal constitutive expression in aorta and other large vessels. VMAP-1 is thus a novel vascular adhesion-associated protein that appears to play a critical role in monocyte adhesion to aortic endothelial cells in atherogenesis in vivo.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-1372160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-1473813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-1622542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-1676048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-1690354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-1693467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-1709380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-1752961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-1760836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-1990440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-2052604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-2318980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-2379237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-2460470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-2848806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-3085644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-3276003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-3340147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-7033383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-7506307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-7507411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-7522621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-7530279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-7537936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-7678986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-7683689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-7687058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-7693807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-7962543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-8123647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-8392092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-8479518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-8600538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-8648141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9182678-8675659
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
185
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2069-77
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9182678-Animals,
pubmed-meshheading:9182678-Antibodies, Monoclonal,
pubmed-meshheading:9182678-Aorta,
pubmed-meshheading:9182678-Arteriosclerosis,
pubmed-meshheading:9182678-Cell Adhesion,
pubmed-meshheading:9182678-Cell Adhesion Molecules,
pubmed-meshheading:9182678-Cell Line,
pubmed-meshheading:9182678-Cytokines,
pubmed-meshheading:9182678-Endothelium, Vascular,
pubmed-meshheading:9182678-Humans,
pubmed-meshheading:9182678-Lipopolysaccharides,
pubmed-meshheading:9182678-Mice,
pubmed-meshheading:9182678-Mice, Inbred BALB C,
pubmed-meshheading:9182678-Monocytes,
pubmed-meshheading:9182678-Rabbits
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pubmed:year |
1997
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pubmed:articleTitle |
Novel vascular molecule involved in monocyte adhesion to aortic endothelium in models of atherogenesis.
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pubmed:affiliation |
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University, Stanford, California 94305, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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