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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
18
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pubmed:dateCreated |
1997-6-11
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pubmed:abstractText |
In most cases of centroblastic/centrocytic follicular lymphomas the bcl-2 proto-oncogene (18q21) is translocated to the immunoglobulin JH region of chromosome 14 (14q32). About three quarters of the translocations are concentrated on the 3' nontranslated, a few hundred basepare-long region of bcl-2, the so called major breakpoint region (mbr), the remaining 20-25% is located about 30 kilobases downstream of bcl-2 coding sequences in the minor cluster region (mcr). The majority of the immunoglobulin breakpoints can be found in JH6-4 genes. The polymerase chain reaction method can detect the translocation already in a very few number of cells (> 10(3)). This very sensitive technique makes it possible to detect the translocation in lymphoid/lymphoma of peripheral blood and bone marrow that are missed by other diagnostic methods. This way one can perform a quick, early diagnosis, examine the result of treatments as well as detect the remissions and the possible relapses right at the beginning. All the advantages of this method contribute to a more successful treatment of follicular lymphoma. This present work describes a polymerase chain reaction technique which is capable of a detection of the t(14;18) translocation in a patient of centroblastic/centrocytic lymphoma, moreover shows how this translocation disappears after 4 week of radiotherapy of the patient.
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pubmed:language |
hun
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0030-6002
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
138
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1129-32
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pubmed:dateRevised |
2009-10-21
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pubmed:meshHeading |
pubmed-meshheading:9182282-Chromosomes, Human, Pair 14,
pubmed-meshheading:9182282-Chromosomes, Human, Pair 18,
pubmed-meshheading:9182282-Humans,
pubmed-meshheading:9182282-Lymphoma, B-Cell,
pubmed-meshheading:9182282-Male,
pubmed-meshheading:9182282-Middle Aged,
pubmed-meshheading:9182282-Oncogene Proteins,
pubmed-meshheading:9182282-Polymerase Chain Reaction,
pubmed-meshheading:9182282-Translocation, Genetic
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pubmed:year |
1997
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pubmed:articleTitle |
[Detection of t(14;18) chromosome translocation in follicular lymphoma by polymerase chain reaction].
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pubmed:affiliation |
Debreceni Orvostudományi Egyetem, III. Belgyógyászati Klinika, Molekuláris Biológiai Kutató Laboratórium, Debrecen.
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pubmed:publicationType |
Journal Article,
English Abstract,
Case Reports
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