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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1997-8-20
|
| pubmed:abstractText |
Rectal bleeding in neonates is an alarming event which suggests a possible necrotizing enterocolitis (NEC) but is usually the only symptom of an unexplained colitis characterized endoscopically by ecchymotic mucosal lesions, the so-called 'ecchymotic colitis' (EC). We studied histologically and bacteriologically 18 infants (mean age: 18 days) presenting with rectal bleeding by systematic rectosigmoidoscopy and intestinal biopsies. The 18 infants were hospitalized. Prematurity was found in seven cases and an underlying condition in 14 cases (respiratory distress: six cases; infection: six cases; surgery: two cases). Histology showed a mild to moderate inflammation (10/12) of the mucosa with a prevalence of polymorphonuclear cells (8/10), frequent focal haemorrhages (11/12) and foci of pneumatosis (4/12). Numerous bacteria were seen in the mucus layer focally forming large clusters. Cultures of intestinal biopsies yielded exclusively Enterobacteriaceae species: Escherichia coli (seven cases), Klebsiella spp. (seven cases), and Enterobacter cloacae (three cases); four cases were sterile. Our study demonstrates that neonatal bleeding is associated with endoscopic and histological 'ecchymotic colitis' lesions and with a peculiar microbial flora of EBC strains. EC and necrotizing enterocolitis share similar features raising the question of the link between the two syndromes.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0309-0167
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
30
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
472-7
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9181369-Biopsy,
pubmed-meshheading:9181369-Colitis, Ulcerative,
pubmed-meshheading:9181369-Ecchymosis,
pubmed-meshheading:9181369-Enterobacteriaceae Infections,
pubmed-meshheading:9181369-Female,
pubmed-meshheading:9181369-Histocytochemistry,
pubmed-meshheading:9181369-Humans,
pubmed-meshheading:9181369-Infant,
pubmed-meshheading:9181369-Infant, Newborn,
pubmed-meshheading:9181369-Intestinal Mucosa,
pubmed-meshheading:9181369-Male,
pubmed-meshheading:9181369-Sigmoidoscopy
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Histopathology and microbiology of isolated rectal bleeding in neonates: the so-called 'ecchymotic colitis'.
|
| pubmed:affiliation |
Department of Pathology, Hôpital Necker-Enfants-Malades, Paris, France.
|
| pubmed:publicationType |
Journal Article
|