Linked Life Data

9181051

Source:http://linkedlifedata.com/resource/pubmed/id/9181051

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1997-8-20
pubmed:abstractText
This paper discusses the feasibility of extrapolating to human cancer results obtained concerning the role of proteases in experimental models of invasion and metastasis. It is customary to view metastasis as a series of individual steps, which must be completed in sequence for the process to be successful. The role of proteases in this process is usually studied by testing the blocking effects of various inhibitors on tumor cell invasion of extracellular matrices (ECM), or in assays of "experimental metastasis" (tail vein injections). The tests of invasion, which utilize established tumor cell lines, provide an account of the type of proteases that potentially may be produced by cancer cells, but, as indicated by recent evidence, they do not reflect the much more restricted repertoire of proteases detected by in situ techniques in human cancer cells. It is much more difficult to find in the progression of human cancer the counterpart to the widely used tail vein injection, which purports to test "late" stages of metastasis, since intravasation is most likely a slow, selective process and not a massive flux of a huge number of cells injected under substantial pressure resulting in non-physiological responses. As a rule, therefore, once it is established that an isolated cancer cell can produce a protease, or degrade and invade ECM, the question is whether this process actually occurs according to a model most reflective of the disease studied (such as orthotopic models) and whether this activity is actually present in cancer tissue sections.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0100-879X
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1099-103
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Experimental models of invasion and metastasis; can they provide reliable answers for the role of proteases in cancer?
pubmed:affiliation
Department of Medicine, Rochelle Belfer Chemotherapy Foundation Laboratory, Mount Sinai School of Medicine, New York, NY 10026, USA.
pubmed:publicationType
Journal Article, Comparative Study