Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1997-6-27
|
| pubmed:abstractText |
The prevalence of Epstein-Barr virus (EBV) and the recently identified Kaposi's sarcoma (KS)-associated herpesvirus (also designated human herpesvirus 8 [HHV-8]) was determined in oral lesions and oral neoplasms common to persons with human immunodeficiency virus (HIV) infection. Oral lesions were examined by polymerase chain reaction (PCR) for EBV and HHV-8 DNA and by Southern blot analysis for EBV clonality. EBV was detected by Southern blot in hairy leukoplakia lesions, in a subset of AIDS-related lymphomas, and in saliva from HIV-positive persons but not in pseudohairy leukoplakia lesions, oral aphthous ulcers, or oral KS lesions. EBV was detected, however, by PCR in most of the lesions, while HHV-8 was detected only in oral KSs. The absence of HHV-8 DNA in both the EBV-associated hairy leukoplakia lesions and in the EBV-associated AIDS-related lymphomas strengthens the etiologic relationship of EBV to these pathologies and the etiologic role of HHV-8 in KS.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0022-1899
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
175
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1324-32
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9180170-AIDS-Related Opportunistic Infections,
pubmed-meshheading:9180170-Cloning, Molecular,
pubmed-meshheading:9180170-DNA, Viral,
pubmed-meshheading:9180170-Herpesviridae Infections,
pubmed-meshheading:9180170-Herpesvirus 4, Human,
pubmed-meshheading:9180170-Herpesvirus 8, Human,
pubmed-meshheading:9180170-Humans,
pubmed-meshheading:9180170-Leukoplakia, Hairy,
pubmed-meshheading:9180170-Lymphoma, AIDS-Related,
pubmed-meshheading:9180170-Male,
pubmed-meshheading:9180170-Mouth Diseases,
pubmed-meshheading:9180170-Mouth Mucosa,
pubmed-meshheading:9180170-Polymerase Chain Reaction,
pubmed-meshheading:9180170-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:9180170-Sarcoma, Kaposi,
pubmed-meshheading:9180170-Sequence Analysis, DNA,
pubmed-meshheading:9180170-Tumor Virus Infections
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Epstein-Barr virus and human herpesvirus 8 prevalence in human immunodeficiency virus-associated oral mucosal lesions.
|
| pubmed:affiliation |
Department of Microbiology and Immunology and Lineberger Cancer Center, University of North Carolina at Chapel Hill, 27599-7295, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|