Linked Life Data

9179352

Source:http://linkedlifedata.com/resource/pubmed/id/9179352

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1997-8-26
pubmed:abstractText
The stability of pentoxifylline in an extemporaneously prepared suspension was studied. Twelve 400-mg pentoxifylline tablets were crushed and mixed with water to prepare a 20-mg/mL suspension. The suspension was transferred to 10 amber glass and 10 amber plastic prescription bottles. Five glass and five plastic bottles were stored at 25 degrees C, and the rest were stored at 4 degrees C. Samples were collected before storage and on days 7, 14, 21, 28, 42, 56, 70, and 91 and analyzed in duplicate by stability-indicating reverse-phase high-performance liquid chromatography. Pentoxifylline was stable in the suspension under all storage conditions for the duration of the study. The color, odor, and pH of the suspension did not change appreciably. Some settling of the suspension was noted in all bottles beginning on day 21, but shaking resuspended the settled material. Pentoxifylline 20 mg/mL was stable in an extemporaneously prepared suspension for at least 91 days at 25 or 4 degrees C.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1079-2082
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1301-3
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Stability of pentoxifylline in an extemporaneously prepared oral suspension.
pubmed:affiliation
Ohio State University, Columbus 43210, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.