| pubmed-article:9178894 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9178894 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9178894 | lifeskim:mentions | umls-concept:C0812287 | lld:lifeskim |
| pubmed-article:9178894 | lifeskim:mentions | umls-concept:C0815000 | lld:lifeskim |
| pubmed-article:9178894 | lifeskim:mentions | umls-concept:C0021701 | lld:lifeskim |
| pubmed-article:9178894 | lifeskim:mentions | umls-concept:C0013081 | lld:lifeskim |
| pubmed-article:9178894 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9178894 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:9178894 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:9178894 | lifeskim:mentions | umls-concept:C1879648 | lld:lifeskim |
| pubmed-article:9178894 | lifeskim:mentions | umls-concept:C0521115 | lld:lifeskim |
| pubmed-article:9178894 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:9178894 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9178894 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9178894 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:9178894 | pubmed:dateCreated | 1997-7-14 | lld:pubmed |
| pubmed-article:9178894 | pubmed:abstractText | Amplification and over-expression of the N-myc oncogene is associated with the progression of neuroblastoma in children and in a nude mouse model system. Neuroblastoma cell lines with widely different levels of N-myc illustrate an inverse relationship between N-myc over-expression and reduced expression of several integrin extracellular matrix receptors. Transfection and over-expression of N-myc in a neuroblastoma cell line not normally expressing the protein resulted in cells that grew loosely associated with tissue culture plates; this correlated with reduced levels of beta1 integrin subunit. Evidence is now presented that alpha2 and alpha3 integrin subunit levels are also reduced in cells that over-express N-myc, with virtually no association of alpha2 or alpha3 subunits with beta1. Consequently, maturation of the beta1 subunit and cell surface expression of the integrins are greatly reduced in N-myc-transfected cells. A small amount of beta1 protein does get to the cell surface, however, suggesting that an as yet unidentified alpha subunit is produced by the N-myc-expressing cells. Finally, the observed reductions in integrin protein levels are reflections of greatly reduced levels of integrin alpha2 and alpha3 mRNAs, as well as a smaller reduction in beta1 mRNA (80%, 94% and 52%, respectively). Post-transcriptional mechanisms modulating beta1 integrin levels are also operative. These results indicate that over-expression of N-myc from a transfected gene in a neuroblastoma cell line that does not normally produce the protein generates cell lines with many of the characteristics of naturally metastatic cells with amplified N-myc genes. Modulation of N-myc and integrin expressions may play a significant role in progression of human neuroblastoma. | lld:pubmed |
| pubmed-article:9178894 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9178894 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9178894 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9178894 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9178894 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9178894 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9178894 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9178894 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9178894 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9178894 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9178894 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9178894 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9178894 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9178894 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:9178894 | pubmed:author | pubmed-author:CulpL ALA | lld:pubmed |
| pubmed-article:9178894 | pubmed:author | pubmed-author:JudwareRR | lld:pubmed |
| pubmed-article:9178894 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9178894 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:9178894 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:9178894 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9178894 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9178894 | pubmed:pagination | 1341-50 | lld:pubmed |
| pubmed-article:9178894 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9178894 | pubmed:meshHeading | pubmed-meshheading:9178894-... | lld:pubmed |
| pubmed-article:9178894 | pubmed:meshHeading | pubmed-meshheading:9178894-... | lld:pubmed |
| pubmed-article:9178894 | pubmed:meshHeading | pubmed-meshheading:9178894-... | lld:pubmed |
| pubmed-article:9178894 | pubmed:meshHeading | pubmed-meshheading:9178894-... | lld:pubmed |
| pubmed-article:9178894 | pubmed:meshHeading | pubmed-meshheading:9178894-... | lld:pubmed |
| pubmed-article:9178894 | pubmed:meshHeading | pubmed-meshheading:9178894-... | lld:pubmed |
| pubmed-article:9178894 | pubmed:meshHeading | pubmed-meshheading:9178894-... | lld:pubmed |
| pubmed-article:9178894 | pubmed:meshHeading | pubmed-meshheading:9178894-... | lld:pubmed |
| pubmed-article:9178894 | pubmed:meshHeading | pubmed-meshheading:9178894-... | lld:pubmed |
| pubmed-article:9178894 | pubmed:meshHeading | pubmed-meshheading:9178894-... | lld:pubmed |
| pubmed-article:9178894 | pubmed:meshHeading | pubmed-meshheading:9178894-... | lld:pubmed |
| pubmed-article:9178894 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9178894 | pubmed:articleTitle | Concomitant down-regulation of expression of integrin subunits by N-myc in human neuroblastoma cells: differential regulation of alpha2, alpha3 and beta1. | lld:pubmed |
| pubmed-article:9178894 | pubmed:affiliation | Case Western Reserve University, School of Medicine, Department of Molecular Biology and Microbiology, Cleveland, Ohio 44106, USA. | lld:pubmed |
| pubmed-article:9178894 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9178894 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9178894 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9178894 | lld:pubmed |
