| pubmed-article:9178254 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9178254 | lifeskim:mentions | umls-concept:C0015677 | lld:lifeskim |
| pubmed-article:9178254 | lifeskim:mentions | umls-concept:C0009015 | lld:lifeskim |
| pubmed-article:9178254 | lifeskim:mentions | umls-concept:C0222679 | lld:lifeskim |
| pubmed-article:9178254 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:9178254 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9178254 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:9178254 | lifeskim:mentions | umls-concept:C1417166 | lld:lifeskim |
| pubmed-article:9178254 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:9178254 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:9178254 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:9178254 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9178254 | lifeskim:mentions | umls-concept:C1710052 | lld:lifeskim |
| pubmed-article:9178254 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9178254 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9178254 | pubmed:dateCreated | 1997-7-29 | lld:pubmed |
| pubmed-article:9178254 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9178254 | pubmed:abstractText | The Drosophila fat facets (faf) gene is a ubiquitin-specific protease necessary for the normal development of the eye and of the syncytial stage embryo in the fly. Using a gene trap approach in embryonic stem cells we have isolated a murine gene with extensive sequence similarity to the Drosophila faf gene and called it Fam (fat facets in mouse). The putative mouse protein shows colinearity and a high degree of sequence identity to the Drosophila protein over almost its entire length of 2554 amino acids. The two enzymatic sites characteristic of ubiquitin-specific proteases are very highly conserved between mice and Drosophila and this conservation extends to yeast. Fam is expressed in a complex pattern during postimplantation development. In situ hybridisation detected Fam transcripts in the rapidly expanding cell populations of gastrulating and neurulating embryos, in post-mitotic cells of the CNS as well as in the apoptotic regions between the digits, indicating that it is not associated with a single developmental or cellular event. The strong sequence similarity to faf and the developmentally regulated expression pattern suggest that Fam and the ubiquitin pathway may play a role in determining cell fate in mammals, as has been established for Drosophila. | lld:pubmed |
| pubmed-article:9178254 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9178254 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9178254 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9178254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9178254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9178254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9178254 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9178254 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:9178254 | pubmed:issn | 0925-4773 | lld:pubmed |
| pubmed-article:9178254 | pubmed:author | pubmed-author:YamadaTT | lld:pubmed |
| pubmed-article:9178254 | pubmed:author | pubmed-author:KemlerRR | lld:pubmed |
| pubmed-article:9178254 | pubmed:author | pubmed-author:MattickJ SJS | lld:pubmed |
| pubmed-article:9178254 | pubmed:author | pubmed-author:WoodS ASA | lld:pubmed |
| pubmed-article:9178254 | pubmed:author | pubmed-author:TOSS | lld:pubmed |
| pubmed-article:9178254 | pubmed:author | pubmed-author:PascoeW SWS | lld:pubmed |
| pubmed-article:9178254 | pubmed:author | pubmed-author:HirchenhainJJ | lld:pubmed |
| pubmed-article:9178254 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9178254 | pubmed:volume | 63 | lld:pubmed |
| pubmed-article:9178254 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9178254 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9178254 | pubmed:pagination | 29-38 | lld:pubmed |
| pubmed-article:9178254 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:9178254 | pubmed:meshHeading | pubmed-meshheading:9178254-... | lld:pubmed |
| pubmed-article:9178254 | pubmed:meshHeading | pubmed-meshheading:9178254-... | lld:pubmed |
| pubmed-article:9178254 | pubmed:meshHeading | pubmed-meshheading:9178254-... | lld:pubmed |
| pubmed-article:9178254 | pubmed:meshHeading | pubmed-meshheading:9178254-... | lld:pubmed |
| pubmed-article:9178254 | pubmed:meshHeading | pubmed-meshheading:9178254-... | lld:pubmed |
| pubmed-article:9178254 | pubmed:meshHeading | pubmed-meshheading:9178254-... | lld:pubmed |
| pubmed-article:9178254 | pubmed:meshHeading | pubmed-meshheading:9178254-... | lld:pubmed |
| pubmed-article:9178254 | pubmed:meshHeading | pubmed-meshheading:9178254-... | lld:pubmed |
| pubmed-article:9178254 | pubmed:meshHeading | pubmed-meshheading:9178254-... | lld:pubmed |
| pubmed-article:9178254 | pubmed:meshHeading | pubmed-meshheading:9178254-... | lld:pubmed |
| pubmed-article:9178254 | pubmed:meshHeading | pubmed-meshheading:9178254-... | lld:pubmed |
| pubmed-article:9178254 | pubmed:meshHeading | pubmed-meshheading:9178254-... | lld:pubmed |
| pubmed-article:9178254 | pubmed:meshHeading | pubmed-meshheading:9178254-... | lld:pubmed |
| pubmed-article:9178254 | pubmed:meshHeading | pubmed-meshheading:9178254-... | lld:pubmed |
| pubmed-article:9178254 | pubmed:meshHeading | pubmed-meshheading:9178254-... | lld:pubmed |
| pubmed-article:9178254 | pubmed:meshHeading | pubmed-meshheading:9178254-... | lld:pubmed |
| pubmed-article:9178254 | pubmed:meshHeading | pubmed-meshheading:9178254-... | lld:pubmed |
| pubmed-article:9178254 | pubmed:meshHeading | pubmed-meshheading:9178254-... | lld:pubmed |
| pubmed-article:9178254 | pubmed:meshHeading | pubmed-meshheading:9178254-... | lld:pubmed |
| pubmed-article:9178254 | pubmed:meshHeading | pubmed-meshheading:9178254-... | lld:pubmed |
| pubmed-article:9178254 | pubmed:meshHeading | pubmed-meshheading:9178254-... | lld:pubmed |
| pubmed-article:9178254 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9178254 | pubmed:articleTitle | Cloning and expression analysis of a novel mouse gene with sequence similarity to the Drosophila fat facets gene. | lld:pubmed |
| pubmed-article:9178254 | pubmed:affiliation | Centre for Molecular and Cellular Biology, University of Queensland, St Lucia, Australia. svwood@cmcb.uq.edu.au | lld:pubmed |
| pubmed-article:9178254 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9178254 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:9178254 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:14084 | entrezgene:pubmed | pubmed-article:9178254 | lld:entrezgene |
| entrez-gene:22284 | entrezgene:pubmed | pubmed-article:9178254 | lld:entrezgene |
| entrez-gene:60728 | entrezgene:pubmed | pubmed-article:9178254 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9178254 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9178254 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9178254 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9178254 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9178254 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9178254 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9178254 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9178254 | lld:pubmed |
