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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1997-6-25
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pubmed:databankReference |
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pubmed:abstractText |
We isolated a cDNA encoding a human homologue of ZF5 (hZF5), which has five Kruppel-like C2H2 type zinc fingers at carboxyl terminus and the BTB/POZ (poxvirus and zinc finger) at the amino terminus, using autoimmune sera from a patient with overlap syndrome (dermatomyositis and scleroderma). Sequencing of the entire cDNA revealed an open reading frame (ORF) of 1349 bp with a deduced protein sequence of 449 amino acid residues and a calculated molecular weight of 51.3 kDa. The deduced amino acid sequence of hZF5 is highly homologous to mouse ZF5 (99.3% identity). Immunofluorescence studies revealed that HA-tagged hZF5 transiently expressed in COS-7 cells showed the nuclear dot pattern in the BTB/POZ domain-dependent manner.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bric-a-brac protein 1, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Immune Sera,
http://linkedlifedata.com/resource/pubmed/chemical/Kruppel-Like Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/ZFP161 protein, human
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0006-3002
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
1352
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
23-6
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9177479-Adult,
pubmed-meshheading:9177479-Amino Acid Sequence,
pubmed-meshheading:9177479-Animals,
pubmed-meshheading:9177479-Base Sequence,
pubmed-meshheading:9177479-COS Cells,
pubmed-meshheading:9177479-Cloning, Molecular,
pubmed-meshheading:9177479-DNA, Complementary,
pubmed-meshheading:9177479-DNA-Binding Proteins,
pubmed-meshheading:9177479-Drosophila Proteins,
pubmed-meshheading:9177479-Female,
pubmed-meshheading:9177479-Fluorescent Antibody Technique,
pubmed-meshheading:9177479-Humans,
pubmed-meshheading:9177479-Immune Sera,
pubmed-meshheading:9177479-Kruppel-Like Transcription Factors,
pubmed-meshheading:9177479-Molecular Sequence Data,
pubmed-meshheading:9177479-Repressor Proteins,
pubmed-meshheading:9177479-Transcription Factors,
pubmed-meshheading:9177479-Zinc Fingers
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pubmed:year |
1997
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pubmed:articleTitle |
Expression cloning and intracellular localization of a human ZF5 homologue.
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pubmed:affiliation |
Department of Anatomy, Nagoya University School of Medicine, Showa-ku, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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