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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1997-6-19
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pubmed:abstractText |
Autoantibodies against complete p53 protein and 18-mer peptides of p53 in ovarian cancer patients and healthy women were examined. Sera from 9% (4/46) of ovarian cancer patients but none (0/51) of healthy women recognized complete p53 protein. The antibodies were mainly of the IgG1 isotype. Two patients had also IgG2 antibodies. Sera from 28% (13/46) of cancer patients and 21% (11/52) of healthy women contained either IgM, or IgM plus IgG2 antibodies against 18-mer p53 peptides. Screening against complete p53 protein instead of peptides seems necessary for identifying patients with tumor-related antibodies. IgG2 antibodies against p53 suggest p53-specific CD4+ T helper 1 cell activity in some of the ovarian cancer patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0304-3835
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pubmed:author |
pubmed-author:DrijfhoutJ WJW,
pubmed-author:HilgersJJ,
pubmed-author:KastW MWM,
pubmed-author:KenemansPP,
pubmed-author:MeliefC JCJ,
pubmed-author:NijmanH WHW,
pubmed-author:VennegoorC JCJ,
pubmed-author:VerheijenR HRH,
pubmed-author:VernieLL,
pubmed-author:VerstraetenR ARA,
pubmed-author:von Mensdorff-PouillySS
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
116
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
93-101
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
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pubmed:year |
1997
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pubmed:articleTitle |
Autoantibodies to p53 in ovarian cancer patients and healthy women: a comparison between whole p53 protein and 18-mer peptides for screening purposes.
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pubmed:affiliation |
Department of Obstetrics and Gynecology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands. c.vennegoor@azvu.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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