Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1997-7-10
pubmed:abstractText
We have studied mechanisms by which leptin overexpression, which reduces body weight via anorexic and thermogenic actions, induces triglyceride depletion in adipocytes and nonadipocytes. Here we show that leptin alters in pancreatic islets the mRNA of the genes encoding enzymes of free fatty acid metabolism and uncoupling protein-2 (UCP-2). In animals infused with a recombinant adenovirus containing the leptin cDNA, the levels of mRNAs encoding enzymes of mitochondrial and peroxisomal oxidation rose 2- to 3-fold, whereas mRNA encoding an enzyme of esterification declined in islets from hyperleptinemic rats. Islet UCP-2 mRNA rose 6-fold. All in vivo changes occurred in vitro in normal islets cultured with recombinant leptin, indicating direct extraneural effects. Leptin overexpression increased UCP-2 mRNA by more than 10-fold in epididymal, retroperitoneal, and subcutaneous fat tissue of normal, but not of leptin-receptor-defective obese rats. By directly regulating the expression of enzymes of free fatty acid metabolism and of UCP-2, leptin controls intracellular triglyceride content of certain nonadipocytes, as well as adipocytes.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177227-6157353, http://linkedlifedata.com/resource/pubmed/commentcorrection/9177227-7004962, http://linkedlifedata.com/resource/pubmed/commentcorrection/9177227-7584987, http://linkedlifedata.com/resource/pubmed/commentcorrection/9177227-7621989, http://linkedlifedata.com/resource/pubmed/commentcorrection/9177227-7624776, http://linkedlifedata.com/resource/pubmed/commentcorrection/9177227-7624777, http://linkedlifedata.com/resource/pubmed/commentcorrection/9177227-7624778, http://linkedlifedata.com/resource/pubmed/commentcorrection/9177227-7768881, http://linkedlifedata.com/resource/pubmed/commentcorrection/9177227-7836394, http://linkedlifedata.com/resource/pubmed/commentcorrection/9177227-7926726, http://linkedlifedata.com/resource/pubmed/commentcorrection/9177227-7971976, http://linkedlifedata.com/resource/pubmed/commentcorrection/9177227-7984236, http://linkedlifedata.com/resource/pubmed/commentcorrection/9177227-8013751, http://linkedlifedata.com/resource/pubmed/commentcorrection/9177227-8621426, http://linkedlifedata.com/resource/pubmed/commentcorrection/9177227-8663251, http://linkedlifedata.com/resource/pubmed/commentcorrection/9177227-8673096, http://linkedlifedata.com/resource/pubmed/commentcorrection/9177227-8702421, http://linkedlifedata.com/resource/pubmed/commentcorrection/9177227-8702432, http://linkedlifedata.com/resource/pubmed/commentcorrection/9177227-8898192, http://linkedlifedata.com/resource/pubmed/commentcorrection/9177227-8962134, http://linkedlifedata.com/resource/pubmed/commentcorrection/9177227-9032096, http://linkedlifedata.com/resource/pubmed/commentcorrection/9177227-9054939, http://linkedlifedata.com/resource/pubmed/commentcorrection/9177227-9114043
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
94
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6386-90
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:9177227-Adipocytes, pubmed-meshheading:9177227-Animals, pubmed-meshheading:9177227-Cells, Cultured, pubmed-meshheading:9177227-DNA Primers, pubmed-meshheading:9177227-Diabetes Mellitus, Type 1, pubmed-meshheading:9177227-Enzyme Induction, pubmed-meshheading:9177227-Epididymis, pubmed-meshheading:9177227-Fatty Acids, Nonesterified, pubmed-meshheading:9177227-Homozygote, pubmed-meshheading:9177227-Ion Channels, pubmed-meshheading:9177227-Islets of Langerhans, pubmed-meshheading:9177227-Leptin, pubmed-meshheading:9177227-Male, pubmed-meshheading:9177227-Membrane Transport Proteins, pubmed-meshheading:9177227-Mitochondria, pubmed-meshheading:9177227-Mitochondrial Proteins, pubmed-meshheading:9177227-Obesity, pubmed-meshheading:9177227-Palmitic Acid, pubmed-meshheading:9177227-Peritoneal Cavity, pubmed-meshheading:9177227-Polymerase Chain Reaction, pubmed-meshheading:9177227-Protein Biosynthesis, pubmed-meshheading:9177227-Proteins, pubmed-meshheading:9177227-RNA, Messenger, pubmed-meshheading:9177227-Rats, pubmed-meshheading:9177227-Rats, Zucker, pubmed-meshheading:9177227-Recombinant Proteins, pubmed-meshheading:9177227-Skin, pubmed-meshheading:9177227-Transcription, Genetic, pubmed-meshheading:9177227-Transfection
pubmed:year
1997
pubmed:articleTitle
Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation.
pubmed:affiliation
Gifford Laboratories, Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.