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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1997-7-10
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pubmed:databankReference |
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pubmed:abstractText |
The atypical protein kinase C (PKC) member PKC-zeta has been implicated in several signal transduction pathways regulating differentiation, proliferation or apoptosis of mammalian cells. We report here the identification of a cytoplasmic and membrane-associated protein that we name zeta-interacting protein (ZIP) and that interacts with the regulatory domain of PKC-zeta but not classic PKCs. The structural motifs in ZIP include a recently defined ZZ zinc finger as a potential protein binding module, two PEST sequences and a novel putative protein binding motif with the consensus sequence YXDEDX5SDEE/D. ZIP binds to the pseudosubstrate region in the regulatory domain of PKC-zeta and is phosphorylated by PKC-zeta in vitro. ZIP dimerizes via the same region that promotes binding to PKC-zeta suggesting a competitive situation between ZIP:ZIP and ZIP:PKC-zeta complexes. In the absence of PKC-zeta proper subcellular localization of ZIP is impaired and we show that intracellular targeting of ZIP is dependent on a balanced interaction with PKC-zeta. Taking into account the recent isolation of ZIP by others in different contexts we propose that ZIP may function as a scaffold protein linking PKC-zeta to protein tyrosine kinases and cytokine receptors.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-1411571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-14732097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-1590767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-1755844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-2231712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-3047011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-3755379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-3755547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-3915782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-7478578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-7499418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-7522330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-7542586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-7565764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-7639744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-7688666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-7701566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-7716516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-7730383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-7744003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-7759517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-7784066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-7803764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-7811263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-7822288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-7834746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-7834747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-7844141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-7862439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-7923372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-7936644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-7982876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-8034680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-8110755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-8280052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-8380153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-8484714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-8524286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-8551575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-8557035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-8566424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-8566425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-8650207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-8666230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-8670417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-8679714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-8797824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-8806656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9177193-8848831
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6191-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9177193-Humans,
pubmed-meshheading:9177193-Animals,
pubmed-meshheading:9177193-Alanine,
pubmed-meshheading:9177193-Rats,
pubmed-meshheading:9177193-Aspartic Acid,
pubmed-meshheading:9177193-Phosphorylation,
pubmed-meshheading:9177193-Saccharomyces cerevisiae,
pubmed-meshheading:9177193-Amino Acid Sequence,
pubmed-meshheading:9177193-Binding Sites,
pubmed-meshheading:9177193-Molecular Sequence Data,
pubmed-meshheading:9177193-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:9177193-Carrier Proteins
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