|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1997-7-31
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|
pubmed:abstractText |
Based on preclinical studies showing synergism between cisplatin and etoposide, we randomized patients with non small cell lung cancer (NSCLC) to receive either the above combination (cisplatin 100 mg/m2 day 1, etoposide 130 mg/m2 days 1-3) or the combination of cisplatin-mitomycin-c and vinca drugs (MVP) (cisplatin 100 mg/m2, vinblastine 6 mg/m2, mitomycin 10 mg/m2 day 1), a regimen with a steady response rate. Partial responses were achieved in 12/44 (27%) of the cisplatin-etoposide group and in 11/43 (26%) of the MVR group. No difference in median survival could be demonstrated between the two groups (36 weeks versus 38 weeks). Myelotoxicity and alopecia were more severe in the cisplatin-etoposide group. Compared to international experience both regimens exhibited a relatively low response rate. It seems that for NSCLC new agents are required.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
1120-009X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
9
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
102-5
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|
pubmed:dateRevised |
2009-8-4
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|
pubmed:meshHeading |
pubmed-meshheading:9176747-Aged,
pubmed-meshheading:9176747-Antibiotics, Antineoplastic,
pubmed-meshheading:9176747-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:9176747-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:9176747-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:9176747-Cisplatin,
pubmed-meshheading:9176747-Disease Progression,
pubmed-meshheading:9176747-Etoposide,
pubmed-meshheading:9176747-Female,
pubmed-meshheading:9176747-Follow-Up Studies,
pubmed-meshheading:9176747-Humans,
pubmed-meshheading:9176747-Lung Neoplasms,
pubmed-meshheading:9176747-Male,
pubmed-meshheading:9176747-Middle Aged,
pubmed-meshheading:9176747-Mitomycins,
pubmed-meshheading:9176747-Prospective Studies,
pubmed-meshheading:9176747-Survival Rate,
pubmed-meshheading:9176747-Vinblastine
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|
pubmed:year |
1997
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|
pubmed:articleTitle |
Chemotherapy of non small cell lung cancer. A prospectively randomized study of cisplatin-etoposide versus cisplatin-mitomycin-vinblastine.
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|
pubmed:affiliation |
Ist Dept. of Propedeutic Medicine, Athens University School of Medicine, Laikon Hospital, Greece.
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|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Clinical Trial, Phase III
|
